MeSH Browser

MeSH Heading: Acute-Phase Proteins
Tree Number(s): D12.776.124.050
Unique ID: D000209
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000209
Annotation: blood proteins; /‌biosyn /‌drug eff /‌physiol permitted
Scope Note: Proteins that are secreted into the blood in increased or decreased quantities by hepatocytes in response to trauma, inflammation, or disease. These proteins can serve as inhibitors or mediators of the inflammatory processes. Certain acute-phase proteins have been used to diagnose and follow the course of diseases or as tumor markers.
Entry Term(s): Acute Phase Reactant; Acute-Phase Glycoprotein; Acute-Phase Glycoproteins; Acute-Phase Protein; Acute-Phase Reactant; Acute-Phase Reactants; Proteins, Acute-Phase; Reactants, Acute-Phase
Registry Numbers: 0
NLM Classification #: WH 400
Previous Indexing: Blood Proteins (1966-1986); C-Reactive Protein (1966-1986); Glycoproteins (1966-1986)
Public MeSH Note: 87
History Note: 87
Date Established: 1987/01/01
Date of Entry: 1986/04/14
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0000324
Registry Numbers: 0
Scope Note: Proteins that are secreted into the blood in increased or decreased quantities by hepatocytes in response to trauma, inflammation, or disease. These proteins can serve as inhibitors or mediators of the inflammatory processes. Certain acute-phase proteins have been used to diagnose and follow the course of diseases or as tumor markers.
Terms: Acute-Phase Proteins Preferred Term
Term UI T000607
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1987); Acute-Phase Reactant
Term UI T000997731
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021); Acute-Phase Protein
Term UI T000605
Date10/12/1989
LexicalTag NON
ThesaurusID NLM (1989); Proteins, Acute-Phase
Term UI T000606
Date04/14/1986
LexicalTag NON
ThesaurusID UNK (19XX); Acute-Phase Reactants
Term UI T000608
Date04/14/1986
LexicalTag NON
ThesaurusID UNK (19XX); Reactants, Acute-Phase
Term UI T000609
Date04/14/1986
LexicalTag NON
ThesaurusID UNK (19XX); Acute Phase Reactant
Term UI T000998553
Date11/21/2019
LexicalTag NON
ThesaurusID NLM (2021)

Acute-Phase Proteins MeSH Descriptor Data 2025