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Complement Pathway, Classical MeSH Descriptor Data 2023

MeSH Heading
Complement Pathway, Classical
Tree Number(s)
Unique ID
RDF Unique Identifier
Scope Note
Complement activation initiated by the binding of COMPLEMENT C1 to ANTIGEN-ANTIBODY COMPLEXES at the COMPLEMENT C1Q subunit. This leads to the sequential activation of COMPLEMENT C1R and COMPLEMENT C1S subunits. Activated C1s cleaves COMPLEMENT C4 and COMPLEMENT C2 forming the membrane-bound classical C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.
Entry Term(s)
Classical Complement Activation Pathway
Classical Complement Pathway
Complement Activation Pathway, Classical
NLM Classification #
QW 680
Previous Indexing
Complement (1966-1978)
Complement Fixation Tests (1966-1978)
Public MeSH Note
91; was see under COMPLEMENT ACTIVATION 1979-90
History Note
91(79); was see under COMPLEMENT ACTIVATION 1979-90
Date Established
Date of Entry
Revision Date
Complement Pathway, Classical Preferred
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