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Complement Pathway, Alternative MeSH Descriptor Data 2023


MeSH Heading
Complement Pathway, Alternative
Tree Number(s)
G12.274.695
Unique ID
D003170
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D003170
Scope Note
Complement activation initiated by the interaction of microbial ANTIGENS with COMPLEMENT C3B. When COMPLEMENT FACTOR B binds to the membrane-bound C3b, COMPLEMENT FACTOR D cleaves it to form alternative C3 CONVERTASE (C3BBB) which, stabilized by COMPLEMENT FACTOR P, is able to cleave multiple COMPLEMENT C3 to form alternative C5 CONVERTASE (C3BBB3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.
Entry Term(s)
Alternative Complement Activation Pathway
Alternative Complement Pathway
Complement Activation Pathway, Alternative
Properdin Pathway
Previous Indexing
Complement (1966-1978)
Complement Fixation Tests (1966-1978)
Public MeSH Note
91; was see under COMPLEMENT ACTIVATION 1979-90
History Note
91(79); was see under COMPLEMENT ACTIVATION 1979-90
Date Established
1991/01/01
Date of Entry
1977/12/02
Revision Date
2016/06/23
Complement Pathway, Alternative Preferred
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