MeSH Browser

MeSH Heading: Complement Pathway, Alternative
Tree Number(s): G12.274.695
Unique ID: D003170
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D003170
Scope Note: Complement activation initiated by the interaction of microbial ANTIGENS with COMPLEMENT C3B. When COMPLEMENT FACTOR B binds to the membrane-bound C3b, COMPLEMENT FACTOR D cleaves it to form alternative C3 CONVERTASE (C3BBB) which, stabilized by COMPLEMENT FACTOR P, is able to cleave multiple COMPLEMENT C3 to form alternative C5 CONVERTASE (C3BBB3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.
Entry Term(s): Alternative Complement Activation Pathway; Alternative Complement Pathway; Complement Activation Pathway, Alternative; Properdin Pathway
Previous Indexing: Complement (1966-1978); Complement Fixation Tests (1966-1978)
Public MeSH Note: 91; was see under COMPLEMENT ACTIVATION 1979-90
History Note: 91(79); was see under COMPLEMENT ACTIVATION 1979-90
Date Established: 1991/01/01
Date of Entry: 1977/12/02
Revision Date: 2016/06/23

Allowable Qualifiers: drug effects (DE)

ethics (ES)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Complement Pathway, Alternative MeSH Descriptor Data 2025