MeSH Browser

MeSH Heading: Prekallikrein
Tree Number(s): D08.622.658; D08.811.277.656.300.760.442.725; D08.811.277.656.959.350.442.725; D12.776.124.125.597.712; D12.776.811.243.658; D23.119.597.712
Unique ID: D011288
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D011288
Scope Note: A plasma protein which is the precursor of kallikrein. Plasma that is deficient in prekallikrein has been found to be abnormal in thromboplastin formation, kinin generation, evolution of a permeability globulin, and plasmin formation. The absence of prekallikrein in plasma leads to Fletcher factor deficiency, a congenital disease.
Entry Term(s): Fletcher Factor; Kallikreinogen; Plasma Prokallikrein; Plasma Prokallikrein A
Registry Numbers: 9055-02-1; 0
CAS Type 1 Name: Kallikreinogen
Previous Indexing: Blood Coagulation Factors (1973-1975); Enzyme Precursors (1973-1975); Kallikrein (1973-1975)
See Also: Coagulants
Public MeSH Note: 89; was see under KALLIKREIN 1976-88
History Note: 89(76); was see under KALLIKREINS 1976-88
Date Established: 1989/01/01
Date of Entry: 1975/07/25
Revision Date: 2019/05/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0017530
Registry Numbers: 9055-02-1
Scope Note: A plasma protein which is the precursor of kallikrein. Plasma that is deficient in prekallikrein has been found to be abnormal in thromboplastin formation, kinin generation, evolution of a permeability globulin, and plasmin formation. The absence of prekallikrein in plasma leads to Fletcher factor deficiency, a congenital disease.
Terms: Prekallikrein Preferred Term
Term UI T033278
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1976); Fletcher Factor
Term UI T033275
Date07/16/1975
LexicalTag EPO
ThesaurusID UNK (19XX); Kallikreinogen
Term UI T033276
Date04/27/1981
LexicalTag NON
ThesaurusID UNK (19XX); Plasma Prokallikrein
Term UI T033277
Date05/18/1988
LexicalTag NON
ThesaurusID UNK (19XX)

Prekallikrein MeSH Descriptor Data 2025