MeSH Browser

MeSH Heading: Factor XII
Tree Number(s): D08.622.500; D12.776.124.125.450; D12.776.811.243.500; D23.119.450
Unique ID: D005174
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D005174
Scope Note: Stable blood coagulation factor activated by contact with the subendothelial surface of an injured vessel. Along with prekallikrein, it serves as the contact factor that initiates the intrinsic pathway of blood coagulation. Kallikrein activates factor XII to XIIa. Deficiency of factor XII, also called the Hageman trait, leads to increased incidence of thromboembolic disease. Mutations in the gene for factor XII that appear to increase factor XII amidolytic activity are associated with HEREDITARY ANGIOEDEMA TYPE III.
Entry Term(s): Coagulation Factor XII; Factor 12; Factor Twelve; Hageman Factor
Registry Numbers: 9001-30-3
CAS Type 1 Name: Blood-coagulation factor XII
See Also: Coagulants; Hereditary Angioedema Type III
Public MeSH Note: 66
History Note: 66(64)
Entry Combination: deficiency:Factor XII Deficiency
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2019/05/30

Entry Combination: deficiency:Factor XII Deficiency
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0008158
Registry Numbers: 9001-30-3
Scope Note: Stable blood coagulation factor activated by contact with the subendothelial surface of an injured vessel. Along with prekallikrein, it serves as the contact factor that initiates the intrinsic pathway of blood coagulation. Kallikrein activates factor XII to XIIa. Deficiency of factor XII, also called the Hageman trait, leads to increased incidence of thromboembolic disease. Mutations in the gene for factor XII that appear to increase factor XII amidolytic activity are associated with HEREDITARY ANGIOEDEMA TYPE III.
Terms: Factor XII Preferred Term
Term UI T015845
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1964); Factor 12
Term UI T000913573
Date01/04/2017
LexicalTag NON
ThesaurusID NLM (2018); Factor Twelve
Term UI T000913574
Date01/04/2017
LexicalTag NON
ThesaurusID NLM (2018); Coagulation Factor XII
Term UI T015844
Date07/31/1996
LexicalTag NON
ThesaurusID NLM (1998); Hageman Factor
Term UI T015846
Date03/30/1974
LexicalTag EPO
ThesaurusID UNK (19XX)

Factor XII MeSH Descriptor Data 2025