- Concept UI
- M0024400
- Registry Numbers
- EC 3.4.21.38
- Scope Note
- Activated form of factor XII. In the initial event in the intrinsic pathway of blood coagulation, kallikrein (with cofactor HIGH MOLECULAR WEIGHT KININOGEN) cleaves factor XII to XIIa. Factor XIIa is then further cleaved by kallikrein, plasmin, and trypsin to yield smaller factor XII fragments (Hageman-Factor fragments). These fragments increase the activity of prekallikrein to kallikrein but decrease the procoagulant activity of factor XII.
- Terms
-
Factor XIIa
Preferred Term
Term UI
T047354
Date01/01/1999
LexicalTag
NON
ThesaurusID
NLM (1990)
-
Factor 12A
Term UI
T000913577
Date01/04/2017
LexicalTag
NON
ThesaurusID
NLM (2018)
-
Activated Factor XII
Term UI
T047351
Date04/24/1989
LexicalTag
NON
ThesaurusID
NLM (1990)
-
Factor XII, Activated
Term UI
T047352
Date05/17/1989
LexicalTag
NON
ThesaurusID
NLM (1990)
-
Blood Coagulation Factor XII, Activated
Term UI
T047353
Date04/24/1989
LexicalTag
NON
ThesaurusID
NLM (1990)
-
Prekallikrein Activator
Term UI
T047355
Date04/24/1989
LexicalTag
NON
ThesaurusID
NLM (1990)
-
Factor Twelve A
Term UI
T000913576
Date01/04/2017
LexicalTag
NON
ThesaurusID
NLM (2018)
-
Coagulation Factor XIIa
Term UI
T047356
Date07/31/1996
LexicalTag
NON
ThesaurusID
NLM (1998)