A serine endopeptidase that has a similar cleavage specificity to TRYPSIN, favoring substrates with poly-basic amino acid sequences. Prostasin plays a critical role in activating EPITHELIAL SODIUM CHANNELS through cleavage of the ENAC gamma subunit.
Entry Term(s)
Serine Protease 8
Registry Numbers
EC 3.4.21.-
Public MeSH Note
2026; PROSTASIN was indexed under SERINE ENDOPEPTIDASES 1994-2025
A serine endopeptidase that has a similar cleavage specificity to TRYPSIN, favoring substrates with poly-basic amino acid sequences. Prostasin plays a critical role in activating EPITHELIAL SODIUM CHANNELS through cleavage of the ENAC gamma subunit.
