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A family of serine proteases with specificity for proline-specific cleavage of peptides that are not longer than 30 amino acids. In humans it is broadly distributed in all tissues with higher activity found in the brain.
Entry Term(s)
Post-Proline Cleaving Enzyme
Post-Proline Endopeptidase
Proline Endopeptidase
Proline Specific Endopeptidase
Prolyl Endopeptidase
Prolyl Endopeptidase (Thiol-dependent)
Prolyl Endopeptidase I
Prolyl Oligopeptidase
Registry Numbers
EC 3.4.21.26
Related Numbers
72162-84-6
EC 3.4.21.26
OJQ0VJ822N
Public MeSH Note
2021; PROLYL OLIGOPEPTIDASES was indexed under SERINE ENDOPEPTIDASES 1988-2020; PEPTIDE PEPTIDOHYDROLASES 1980-1987; and under PROLINE 1977-1980
A family of serine proteases with specificity for proline-specific cleavage of peptides that are not longer than 30 amino acids. In humans it is broadly distributed in all tissues with higher activity found in the brain.