MeSH Browser

MeSH Heading: Prolyl Oligopeptidases
Tree Number(s): D08.811.277.656.300.760.637
Unique ID: D000085822
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000085822
Scope Note: A family of serine proteases with specificity for proline-specific cleavage of peptides that are not longer than 30 amino acids. In humans it is broadly distributed in all tissues with higher activity found in the brain.
Entry Term(s): Post-Proline Cleaving Enzyme; Post-Proline Endopeptidase; Proline Endopeptidase; Proline Specific Endopeptidase; Prolyl Endopeptidase; Prolyl Endopeptidase (Thiol-dependent); Prolyl Endopeptidase I; Prolyl Oligopeptidase
Registry Number: EC 3.4.21.26
Related Numbers: 72162-84-6; EC 3.4.21.26; OJQ0VJ822N
Public MeSH Note: 2021; PROLYL OLIGOPEPTIDASES was indexed under SERINE ENDOPEPTIDASES 1988-2020; PEPTIDE PEPTIDOHYDROLASES 1980-1987; and under PROLINE 1977-1980
History Note: 2021
Date Established: 2021/01/01
Date of Entry: 2020/07/07
Revision Date: 2020/06/22

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Peptide Hydrolases [D08.811.277.656]
      - Endopeptidases [D08.811.277.656.300]
        
        Serine Endopeptidases [D08.811.277.656.300.760]
        
        Acrosin [D08.811.277.656.300.760.030]
        
        Cathepsin G [D08.811.277.656.300.760.066]
        
        Chymases [D08.811.277.656.300.760.103]
        
        Chymotrypsin [D08.811.277.656.300.760.176]
        
        Complement Factor B [D08.811.277.656.300.760.198]
        
        Complement Factor D [D08.811.277.656.300.760.200]
        
        Complement Factor I [D08.811.277.656.300.760.210]
        
        Endopeptidase K [D08.811.277.656.300.760.247]
        
        Enteropeptidase [D08.811.277.656.300.760.284]
        
        Factor VIIa [D08.811.277.656.300.760.300]
        
        Factor IXa [D08.811.277.656.300.760.310]
        
        Factor Xa [D08.811.277.656.300.760.315]
        
        Factor XIa [D08.811.277.656.300.760.320]
        
        Factor XIIa [D08.811.277.656.300.760.324]
        
        Fibrinolysin [D08.811.277.656.300.760.330]
        
        Furin [D08.811.277.656.300.760.353]
        
        Granzymes [D08.811.277.656.300.760.397]
        
        High-Temperature Requirement A Serine Peptidase 1 [D08.811.277.656.300.760.420]
        
        High-Temperature Requirement A Serine Peptidase 2 [D08.811.277.656.300.760.431]
        
        Kallikreins [D08.811.277.656.300.760.442]
        
        Lactoferrin [D08.811.277.656.300.760.471]
        
        Mannose-Binding Protein-Associated Serine Proteases [D08.811.277.656.300.760.501]
        
        Myeloblastin [D08.811.277.656.300.760.530]
        
        Pancreatic Elastase [D08.811.277.656.300.760.560]
        
        Plasminogen Activators [D08.811.277.656.300.760.635]
        
        Prolyl Oligopeptidases [D08.811.277.656.300.760.637]
        
        Pronase [D08.811.277.656.300.760.638]
        
        Proprotein Convertase 1 [D08.811.277.656.300.760.640]
        
        Proprotein Convertase 2 [D08.811.277.656.300.760.646]
        
        Proprotein Convertase 5 [D08.811.277.656.300.760.648]
        
        Proprotein Convertase 9 [D08.811.277.656.300.760.718]
        
        Reelin Protein [D08.811.277.656.300.760.753]
        
        Subtilisins [D08.811.277.656.300.760.787]
        
        Thrombin [D08.811.277.656.300.760.855]
        
        Tissue Plasminogen Activator [D08.811.277.656.300.760.875]
        
        Trypsin [D08.811.277.656.300.760.895]
        
        Tryptases [D08.811.277.656.300.760.902]
        
        Urokinase-Type Plasminogen Activator [D08.811.277.656.300.760.910]
        
        Venombin A [D08.811.277.656.300.760.955]

Prolyl Oligopeptidases Preferred

Concept UI: M000731526
Registry Number: EC 3.4.21.26
Related Numbers: 72162-84-6; EC 3.4.21.26; OJQ0VJ822N
Scope Note: A family of serine proteases with specificity for proline-specific cleavage of peptides that are not longer than 30 amino acids. In humans it is broadly distributed in all tissues with higher activity found in the brain.
Terms: Prolyl Oligopeptidases Preferred Term
Term UI T001078186
Date04/08/2020
LexicalTag NON
ThesaurusID NLM (2021); Proline Endopeptidase
Term UI T001078326
Date04/09/2020
LexicalTag NON
ThesaurusID NLM (2021); Proline Specific Endopeptidase
Term UI T001078328
Date04/09/2020
LexicalTag NON
ThesaurusID NLM (2021); Post-Proline Cleaving Enzyme
Term UI T001079171
Date04/22/2020
LexicalTag NON
ThesaurusID NLM (2021); Prolyl Endopeptidase (Thiol-dependent)
Term UI T001078330
Date04/09/2020
LexicalTag NON
ThesaurusID NLM (2021); Prolyl Endopeptidase I
Term UI T001078331
Date04/09/2020
LexicalTag NON
ThesaurusID NLM (2021); Prolyl Oligopeptidase
Term UI T001078332
Date04/09/2020
LexicalTag NON
ThesaurusID NLM (2021); Post-Proline Endopeptidase
Term UI T001079172
Date04/22/2020
LexicalTag NON
ThesaurusID NLM (2021); Prolyl Endopeptidase
Term UI T001078329
Date04/09/2020
LexicalTag NON
ThesaurusID NLM (2021)

Prolyl Oligopeptidases MeSH Descriptor Data 2023