MeSH Browser

MeSH Heading: Proprotein Convertase 1
Tree Number(s): D08.811.277.656.300.760.640; D08.811.277.656.837.500; D08.811.277.656.959.350.640
Unique ID: D045664
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D045664
Scope Note: A CALCIUM-dependent endopeptidase that has specificity for cleavage at ARGININE that is near paired basic residues. It cleaves a variety of prohormones including PRO-OPIOMELANOCORTIN; PRORENIN; proenkephalins; prodynorphin; prosomatostatin; and PROINSULIN.
Entry Term(s): Neuroendocrine Convertase PC1; PC1 Endoprotease; PC1 Prohormone Convertase; PC3 Endoprotease; PC3 Prohormone Convertase; Prohormone Convertase 1; Prohormone Convertase 3; Prohormone Convertase, PC1; Proinsulin Convertase 1; Proprotein Convertase SPC3
Registry Number: EC 3.4.21.93
Previous Indexing: Aspartic Endopeptidases (1991-2003)
Public MeSH Note: 2004; PC1 PROHORMONE CONVERTASE, NEUROENDOCRINE CONVERTASE PC1, PC3 ENDOPROTEASE & PROHORMONE CONVERTASE 1 were indexed under ASPARTIC ENDOPEPTIDASES 1991-2003; PC1 ENDOPROTEASE & PC3 PROHORMONE CONVERTASE were indexed under ASPARTIC ENDOPEPTIDASES 1993-2003; PROPROTEIN CONVERTASE SPC3 was indexed under ASPARTIC ENDOPEPTIDASES 2001-2003; PROINSULIN CONVERTASE 1 was indexed under ASPARTIC ENDOPEPTIDASES 2002-2003;
History Note: 2004; for PC1 PROHORMONE CONVERTASE, NEUROENDOCRINE CONVERTASE PC1, PC3 ENDOPROTEASE, PROHORMONE CONVERTASE 1 use PROPROTEIN CONVERTASE (NM) 1991-2003; for PC1 ENDOPROTEASE & PC3 PROHORMONE CONVERTASE use PROPROTEIN CONVERTASE (NM) 1993-2003; for PROPROTEIN CONVERTASE SPC3 use PROPROTEIN CONVERTASE (NM) 2001-2003; for PROINSULIN CONVERTASE 1 use PROPROTEIN CONVERTASE (NM) 2002-2003
Date Established: 2004/01/01
Date of Entry: 2003/07/09
Revision Date: 2009/07/06

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Peptide Hydrolases [D08.811.277.656]
      - Endopeptidases [D08.811.277.656.300]
        
        Serine Endopeptidases [D08.811.277.656.300.760]
        
        Acrosin [D08.811.277.656.300.760.030]
        
        Cathepsin G [D08.811.277.656.300.760.066]
        
        Chymases [D08.811.277.656.300.760.103]
        
        Chymotrypsin [D08.811.277.656.300.760.176]
        
        Complement Factor B [D08.811.277.656.300.760.198]
        
        Complement Factor D [D08.811.277.656.300.760.200]
        
        Complement Factor I [D08.811.277.656.300.760.210]
        
        Endopeptidase K [D08.811.277.656.300.760.247]
        
        Enteropeptidase [D08.811.277.656.300.760.284]
        
        Factor VIIa [D08.811.277.656.300.760.300]
        
        Factor IXa [D08.811.277.656.300.760.310]
        
        Factor Xa [D08.811.277.656.300.760.315]
        
        Factor XIa [D08.811.277.656.300.760.320]
        
        Factor XIIa [D08.811.277.656.300.760.324]
        
        Fibrinolysin [D08.811.277.656.300.760.330]
        
        Furin [D08.811.277.656.300.760.353]
        
        Granzymes [D08.811.277.656.300.760.397]
        
        High-Temperature Requirement A Serine Peptidase 1 [D08.811.277.656.300.760.420]
        
        High-Temperature Requirement A Serine Peptidase 2 [D08.811.277.656.300.760.431]
        
        Kallikreins [D08.811.277.656.300.760.442]
        
        Lactoferrin [D08.811.277.656.300.760.471]
        
        Mannose-Binding Protein-Associated Serine Proteases [D08.811.277.656.300.760.501]
        
        Myeloblastin [D08.811.277.656.300.760.530]
        
        Pancreatic Elastase [D08.811.277.656.300.760.560]
        
        Plasminogen Activators [D08.811.277.656.300.760.635]
        
        Prolyl Oligopeptidases [D08.811.277.656.300.760.637]
        
        Pronase [D08.811.277.656.300.760.638]
        
        Proprotein Convertase 1 [D08.811.277.656.300.760.640]
        
        Proprotein Convertase 2 [D08.811.277.656.300.760.646]
        
        Proprotein Convertase 5 [D08.811.277.656.300.760.648]
        
        Proprotein Convertase 9 [D08.811.277.656.300.760.718]
        
        Reelin Protein [D08.811.277.656.300.760.753]
        
        Subtilisins [D08.811.277.656.300.760.787]
        
        Thrombin [D08.811.277.656.300.760.855]
        
        Tissue Plasminogen Activator [D08.811.277.656.300.760.875]
        
        Trypsin [D08.811.277.656.300.760.895]
        
        Tryptases [D08.811.277.656.300.760.902]
        
        Urokinase-Type Plasminogen Activator [D08.811.277.656.300.760.910]
        
        Venombin A [D08.811.277.656.300.760.955]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Peptide Hydrolases [D08.811.277.656]
      - Proprotein Convertases [D08.811.277.656.837]
        
        Carboxypeptidase B [D08.811.277.656.837.061]
        
        Carboxypeptidase B2 [D08.811.277.656.837.092]
        
        Carboxypeptidase H [D08.811.277.656.837.124]
        
        Furin [D08.811.277.656.837.249]
        
        Proprotein Convertase 1 [D08.811.277.656.837.500]
        
        Proprotein Convertase 2 [D08.811.277.656.837.562]
        
        Proprotein Convertase 5 [D08.811.277.656.837.625]
        
        Proprotein Convertase 9 [D08.811.277.656.837.688]
        
        Renin [D08.811.277.656.837.750]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Peptide Hydrolases [D08.811.277.656]
      - Serine Proteases [D08.811.277.656.959]
        
        Serine Endopeptidases [D08.811.277.656.959.350]
        
        Acrosin [D08.811.277.656.959.350.030]
        
        Cathepsin G [D08.811.277.656.959.350.066]
        
        Chymases [D08.811.277.656.959.350.103]
        
        Chymotrypsin [D08.811.277.656.959.350.176]
        
        Complement Factor B [D08.811.277.656.959.350.198]
        
        Complement Factor D [D08.811.277.656.959.350.200]
        
        Complement Factor I [D08.811.277.656.959.350.210]
        
        Endopeptidase K [D08.811.277.656.959.350.247]
        
        Enteropeptidase [D08.811.277.656.959.350.284]
        
        Factor VIIa [D08.811.277.656.959.350.300]
        
        Factor IXa [D08.811.277.656.959.350.310]
        
        Factor Xa [D08.811.277.656.959.350.315]
        
        Factor XIa [D08.811.277.656.959.350.320]
        
        Factor XIIa [D08.811.277.656.959.350.324]
        
        Fibrinolysin [D08.811.277.656.959.350.330]
        
        Furin [D08.811.277.656.959.350.353]
        
        Granzymes [D08.811.277.656.959.350.397]
        
        High-Temperature Requirement A Serine Peptidase 1 [D08.811.277.656.959.350.420]
        
        High-Temperature Requirement A Serine Peptidase 2 [D08.811.277.656.959.350.431]
        
        Kallikreins [D08.811.277.656.959.350.442]
        
        Lactoferrin [D08.811.277.656.959.350.471]
        
        Mannose-Binding Protein-Associated Serine Proteases [D08.811.277.656.959.350.501]
        
        Myeloblastin [D08.811.277.656.959.350.530]
        
        Pancreatic Elastase [D08.811.277.656.959.350.560]
        
        Plasminogen Activators [D08.811.277.656.959.350.635]
        
        Pronase [D08.811.277.656.959.350.638]
        
        Proprotein Convertase 1 [D08.811.277.656.959.350.640]
        
        Proprotein Convertase 2 [D08.811.277.656.959.350.646]
        
        Proprotein Convertase 5 [D08.811.277.656.959.350.648]
        
        Proprotein Convertase 9 [D08.811.277.656.959.350.718]
        
        Reelin Protein [D08.811.277.656.959.350.753]
        
        Subtilisins [D08.811.277.656.959.350.787]
        
        Thrombin [D08.811.277.656.959.350.855]
        
        Tissue Plasminogen Activator [D08.811.277.656.959.350.875]
        
        Trypsin [D08.811.277.656.959.350.895]
        
        Tryptases [D08.811.277.656.959.350.902]
        
        Urokinase-Type Plasminogen Activator [D08.811.277.656.959.350.910]
        
        Venombin A [D08.811.277.656.959.350.955]

Proprotein Convertase 1 Preferred

Concept UI: M0103931
Registry Number: EC 3.4.21.93
Scope Note: A CALCIUM-dependent endopeptidase that has specificity for cleavage at ARGININE that is near paired basic residues. It cleaves a variety of prohormones including PRO-OPIOMELANOCORTIN; PRORENIN; proenkephalins; prodynorphin; prosomatostatin; and PROINSULIN.
Terms: Proprotein Convertase 1 Preferred Term
Term UI T540463
Date05/12/2003
LexicalTag NON
ThesaurusID NLM (2004); PC1 Prohormone Convertase
Term UI T133935
LexicalTag ABX
ThesaurusID NLM (2004); PC3 Endoprotease
Term UI T133936
LexicalTag ABX
ThesaurusID NLM (2004); PC3 Prohormone Convertase
Term UI T133938
LexicalTag ABX
ThesaurusID NLM (2004); Neuroendocrine Convertase PC1
Term UI T133944
LexicalTag ABX
ThesaurusID NLM (2004); Proprotein Convertase SPC3
Term UI T461241
Date09/12/2001
LexicalTag ABX
ThesaurusID NLM (2004); Proinsulin Convertase 1
Term UI T485608
Date03/13/2002
LexicalTag NON
ThesaurusID NLM (2004); Prohormone Convertase 3
Term UI T539917
Date05/06/2003
LexicalTag NON
ThesaurusID NLM (2004); Prohormone Convertase, PC1
Term UI T539963
Date05/06/2003
LexicalTag NON
ThesaurusID NLM (2004); PC1 Endoprotease
Term UI T133934
LexicalTag ABX
ThesaurusID NLM (2004); Prohormone Convertase 1
Term UI T133948
LexicalTag NON
ThesaurusID NLM (2004)

Proprotein Convertase 1 MeSH Descriptor Data 2023