- Concept UI
- M000628721
- Registry Numbers
- EC 3.4.21.108
- Scope Note
- A serine peptidase that contains a C-terminal PDZ domain. It localizes to the mitochondrial membrane and intermembrane space, translocating to the cytoplasm following APOPTOSIS stimuli, such as UV irradiation; it promotes cell death by binding to and inhibiting INHIBITOR OF APOPTOSIS PROTEINS, resulting in an increase in activity of CASPASES. Mutations in the HTRA2 gene are associated with Type 13 PARKINSON DISEASE.
- Terms
-
High-Temperature Requirement A Serine Peptidase 2
Preferred Term
Term UI
T000919586
Date03/22/2017
LexicalTag
NON
ThesaurusID
NLM (2018)
-
HtrA Serine Peptidase 2
Term UI
T000919587
Date03/22/2017
LexicalTag
ABX
ThesaurusID
NLM (2006)
-
Omi Serine Protease
Term UI
T000919588
Date03/22/2017
LexicalTag
NON
ThesaurusID
NLM (2000)
-
Serine Protease Omi
Term UI
T000919589
Date03/22/2017
LexicalTag
NON
ThesaurusID
NLM (2000)
-
HtrA2 Protease
Term UI
T000919590
Date03/22/2017
LexicalTag
ABX
ThesaurusID
NLM (2018)
-
Serine Protease HTRA2
Term UI
T000919591
Date03/22/2017
LexicalTag
ABX
ThesaurusID
NLM (2018)