MeSH Browser

MeSH Heading: High-Temperature Requirement A Serine Peptidase 2
Tree Number(s): D08.811.277.656.300.760.431; D08.811.277.656.959.350.431; D12.776.476.075.429; D12.776.575.656; D12.776.705.625
Unique ID: D000074923
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000074923
Scope Note: A serine peptidase that contains a C-terminal PDZ domain. It localizes to the mitochondrial membrane and intermembrane space, translocating to the cytoplasm following APOPTOSIS stimuli, such as UV irradiation; it promotes cell death by binding to and inhibiting INHIBITOR OF APOPTOSIS PROTEINS, resulting in an increase in activity of CASPASES. Mutations in the HTRA2 gene are associated with Type 13 PARKINSON DISEASE.
Entry Term(s): HtrA Serine Peptidase 2; HtrA2 Protease; Omi Serine Protease; Serine Protease HTRA2; Serine Protease Omi
See Also: PDZ Domains
Public MeSH Note: 2018; HIGH-TEMPERATURE REQUIREMENT A SERINE PEPTIDASE 2 was indexed under SERINE ENDOPEPTIDASES and MITOCHONDRIAL PROTEINS 2000-2017
History Note: 2018 (2000)
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2022/07/12

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Peptide Hydrolases [D08.811.277.656]
      - Endopeptidases [D08.811.277.656.300]
        
        Serine Endopeptidases [D08.811.277.656.300.760]
        
        Acrosin [D08.811.277.656.300.760.030]
        
        Cathepsin G [D08.811.277.656.300.760.066]
        
        Chymases [D08.811.277.656.300.760.103]
        
        Chymotrypsin [D08.811.277.656.300.760.176]
        
        Complement Factor B [D08.811.277.656.300.760.198]
        
        Complement Factor D [D08.811.277.656.300.760.200]
        
        Complement Factor I [D08.811.277.656.300.760.210]
        
        Endopeptidase K [D08.811.277.656.300.760.247]
        
        Enteropeptidase [D08.811.277.656.300.760.284]
        
        Factor VIIa [D08.811.277.656.300.760.300]
        
        Factor IXa [D08.811.277.656.300.760.310]
        
        Factor Xa [D08.811.277.656.300.760.315]
        
        Factor XIa [D08.811.277.656.300.760.320]
        
        Factor XIIa [D08.811.277.656.300.760.324]
        
        Fibrinolysin [D08.811.277.656.300.760.330]
        
        Furin [D08.811.277.656.300.760.353]
        
        Granzymes [D08.811.277.656.300.760.397]
        
        High-Temperature Requirement A Serine Peptidase 1 [D08.811.277.656.300.760.420]
        
        High-Temperature Requirement A Serine Peptidase 2 [D08.811.277.656.300.760.431]
        
        Kallikreins [D08.811.277.656.300.760.442]
        
        Lactoferrin [D08.811.277.656.300.760.471]
        
        Mannose-Binding Protein-Associated Serine Proteases [D08.811.277.656.300.760.501]
        
        Myeloblastin [D08.811.277.656.300.760.530]
        
        Pancreatic Elastase [D08.811.277.656.300.760.560]
        
        Plasminogen Activators [D08.811.277.656.300.760.635]
        
        Prolyl Oligopeptidases [D08.811.277.656.300.760.637]
        
        Pronase [D08.811.277.656.300.760.638]
        
        Proprotein Convertase 1 [D08.811.277.656.300.760.640]
        
        Proprotein Convertase 2 [D08.811.277.656.300.760.646]
        
        Proprotein Convertase 5 [D08.811.277.656.300.760.648]
        
        Proprotein Convertase 9 [D08.811.277.656.300.760.718]
        
        Reelin Protein [D08.811.277.656.300.760.753]
        
        Subtilisins [D08.811.277.656.300.760.787]
        
        Thrombin [D08.811.277.656.300.760.855]
        
        Tissue Plasminogen Activator [D08.811.277.656.300.760.875]
        
        Trypsin [D08.811.277.656.300.760.895]
        
        Tryptases [D08.811.277.656.300.760.902]
        
        Urokinase-Type Plasminogen Activator [D08.811.277.656.300.760.910]
        
        Venombin A [D08.811.277.656.300.760.955]

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Hydrolases [D08.811.277]
    - Peptide Hydrolases [D08.811.277.656]
      - Serine Proteases [D08.811.277.656.959]
        
        Serine Endopeptidases [D08.811.277.656.959.350]
        
        Acrosin [D08.811.277.656.959.350.030]
        
        Cathepsin G [D08.811.277.656.959.350.066]
        
        Chymases [D08.811.277.656.959.350.103]
        
        Chymotrypsin [D08.811.277.656.959.350.176]
        
        Complement Factor B [D08.811.277.656.959.350.198]
        
        Complement Factor D [D08.811.277.656.959.350.200]
        
        Complement Factor I [D08.811.277.656.959.350.210]
        
        Endopeptidase K [D08.811.277.656.959.350.247]
        
        Enteropeptidase [D08.811.277.656.959.350.284]
        
        Factor VIIa [D08.811.277.656.959.350.300]
        
        Factor IXa [D08.811.277.656.959.350.310]
        
        Factor Xa [D08.811.277.656.959.350.315]
        
        Factor XIa [D08.811.277.656.959.350.320]
        
        Factor XIIa [D08.811.277.656.959.350.324]
        
        Fibrinolysin [D08.811.277.656.959.350.330]
        
        Furin [D08.811.277.656.959.350.353]
        
        Granzymes [D08.811.277.656.959.350.397]
        
        High-Temperature Requirement A Serine Peptidase 1 [D08.811.277.656.959.350.420]
        
        High-Temperature Requirement A Serine Peptidase 2 [D08.811.277.656.959.350.431]
        
        Kallikreins [D08.811.277.656.959.350.442]
        
        Lactoferrin [D08.811.277.656.959.350.471]
        
        Mannose-Binding Protein-Associated Serine Proteases [D08.811.277.656.959.350.501]
        
        Myeloblastin [D08.811.277.656.959.350.530]
        
        Pancreatic Elastase [D08.811.277.656.959.350.560]
        
        Plasminogen Activators [D08.811.277.656.959.350.635]
        
        Pronase [D08.811.277.656.959.350.638]
        
        Proprotein Convertase 1 [D08.811.277.656.959.350.640]
        
        Proprotein Convertase 2 [D08.811.277.656.959.350.646]
        
        Proprotein Convertase 5 [D08.811.277.656.959.350.648]
        
        Proprotein Convertase 9 [D08.811.277.656.959.350.718]
        
        Reelin Protein [D08.811.277.656.959.350.753]
        
        Subtilisins [D08.811.277.656.959.350.787]
        
        Thrombin [D08.811.277.656.959.350.855]
        
        Tissue Plasminogen Activator [D08.811.277.656.959.350.875]
        
        Trypsin [D08.811.277.656.959.350.895]
        
        Tryptases [D08.811.277.656.959.350.902]
        
        Urokinase-Type Plasminogen Activator [D08.811.277.656.959.350.910]
        
        Venombin A [D08.811.277.656.959.350.955]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Apoptosis Regulatory Proteins [D12.776.476.075]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Mitochondrial Proteins [D12.776.575]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Parkinson Disease Associated Proteins [D12.776.705]

High-Temperature Requirement A Serine Peptidase 2 Preferred

Concept UI: M000628721
Scope Note: A serine peptidase that contains a C-terminal PDZ domain. It localizes to the mitochondrial membrane and intermembrane space, translocating to the cytoplasm following APOPTOSIS stimuli, such as UV irradiation; it promotes cell death by binding to and inhibiting INHIBITOR OF APOPTOSIS PROTEINS, resulting in an increase in activity of CASPASES. Mutations in the HTRA2 gene are associated with Type 13 PARKINSON DISEASE.
Terms: High-Temperature Requirement A Serine Peptidase 2 Preferred Term
Term UI T000919586
Date03/22/2017
LexicalTag NON
ThesaurusID NLM (2018); HtrA Serine Peptidase 2
Term UI T000919587
Date03/22/2017
LexicalTag ABX
ThesaurusID NLM (2006); Omi Serine Protease
Term UI T000919588
Date03/22/2017
LexicalTag NON
ThesaurusID NLM (2000); Serine Protease Omi
Term UI T000919589
Date03/22/2017
LexicalTag NON
ThesaurusID NLM (2000); HtrA2 Protease
Term UI T000919590
Date03/22/2017
LexicalTag ABX
ThesaurusID NLM (2018); Serine Protease HTRA2
Term UI T000919591
Date03/22/2017
LexicalTag ABX
ThesaurusID NLM (2018)

High-Temperature Requirement A Serine Peptidase 2 MeSH Descriptor Data 2025