MeSH Browser

MeSH Heading: Ferrochelatase
Tree Number(s): D08.811.520.500; D12.776.157.427.374.375.957; D12.776.556.579.374.375.617; D12.776.575.562
Unique ID: D005294
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D005294
Scope Note: A mitochondrial enzyme found in a wide variety of cells and tissues. It is the final enzyme in the 8-enzyme biosynthetic pathway of HEME. Ferrochelatase catalyzes ferrous insertion into protoporphyrin IX to form protoheme or heme. Deficiency in this enzyme results in ERYTHROPOIETIC PROTOPORPHYRIA.
Entry Term(s): Heme Synthetase; Porphyrin-Metal Chelatase; Protoheme Ferro-Lyase; Zinc Chelatase
Related Numbers: 9012-93-5; EC 4.99.1.1
CAS Type 1 Name: Protoheme ferro-lyase
Previous Indexing: Iron (1966-1976); Lyases (1966-1976); Porphyrins (1966-1976); Protoporphyrins (1975-1976)
Public MeSH Note: 1991; see LYASES 1977-1990
History Note: 1991(1977); use LYASES 1977-1990
Entry Combination: deficiency:Protoporphyria, Erythropoietic
Date Established: 1991/01/01
Date of Entry: 1976/04/27
Revision Date: 2011/06/24

Entry Combination: deficiency:Protoporphyria, Erythropoietic
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0008356
Related Numbers: 9012-93-5; EC 4.99.1.1
Scope Note: A mitochondrial enzyme found in a wide variety of cells and tissues. It is the final enzyme in the 8-enzyme biosynthetic pathway of HEME. Ferrochelatase catalyzes ferrous insertion into protoporphyrin IX to form protoheme or heme. Deficiency in this enzyme results in ERYTHROPOIETIC PROTOPORPHYRIA.
Terms: Ferrochelatase Preferred Term
Term UI T016182
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1977); Heme Synthetase
Term UI T016183
Date04/26/1976
LexicalTag NON
ThesaurusID UNK (19XX); Porphyrin-Metal Chelatase
Term UI T016184
Date04/26/1976
LexicalTag NON
ThesaurusID UNK (19XX); Protoheme Ferro-Lyase
Term UI T016185
Date12/09/1981
LexicalTag NON
ThesaurusID UNK (19XX)

Ferrochelatase MeSH Descriptor Data 2025