MeSH Browser

MeSH Heading: Sirtuin 3
Tree Number(s): D08.811.277.087.520.200.650.600; D08.811.913.400.725.115.961.600; D12.776.476.900.600; D12.776.575.875
Unique ID: D056566
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D056566
Scope Note: A sirtuin family member found primarily in MITOCHONDRIA. It is a multifunctional enzyme that contains a NAD-dependent deacetylase activity that is specific for HISTONES and a mono-ADP-ribosyltransferase activity.
Entry Term(s): Silent Mating Type Information Regulation 2 Homolog 3; Sirt3
Registry Numbers: EC 3.5.1.-
Related Numbers: EC 2.4.2.-
Previous Indexing: Histone Deacetylases (2002-2005); Mitochondrial Proteins (2006-2009); Sirtuins (2006-2009)
Public MeSH Note: 2010
History Note: 2010
Date Established: 2010/01/01
Date of Entry: 2009/07/06
Revision Date: 2018/06/14

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0527794
Registry Numbers: EC 3.5.1.-
Related Numbers: EC 2.4.2.-
Scope Note: A sirtuin family member found primarily in MITOCHONDRIA. It is a multifunctional enzyme that contains a NAD-dependent deacetylase activity that is specific for HISTONES and a mono-ADP-ribosyltransferase activity.
Terms: Sirtuin 3 Preferred Term
Term UI T732015
Date12/18/2008
LexicalTag NON
ThesaurusID NLM (2010); Silent Mating Type Information Regulation 2 Homolog 3
Term UI T732016
Date12/18/2008
LexicalTag NON
ThesaurusID NLM (2010); Sirt3
Term UI T000941534
Date03/26/2018
LexicalTag NON
ThesaurusID NLM (2019)

Sirtuin 3 MeSH Descriptor Data 2025