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Histone Deacetylases MeSH Descriptor Data 2023

MeSH Heading
Histone Deacetylases
Tree Number(s)
Unique ID
RDF Unique Identifier
Scope Note
Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of HISTONES. The enzyme family can be divided into at least three structurally-defined subclasses. Class I and class II deacetylases utilize a zinc-dependent mechanism. The sirtuin histone deacetylases belong to class III and are NAD-dependent enzymes.
Entry Term(s)
Class I Histone Deacetylases
Class II Histone Deacetylases
HDAC Proteins
Histone Deacetylase
Histone Deacetylase Complexes
Registry Number
Related Numbers
Previous Indexing
Acetic Acids (1971-1974)
Amidohydrolases (1971-1974)
Histones (1971-1974)
Public MeSH Note
2003; see HISTONE DEACETYLASE 1991-2002; see AMIDOHYDROLASES 1975-1990
History Note
2003; use AMIDOHYDROLASES 1975-1990
Entry Combination
antagonists & inhibitors:Histone Deacetylase Inhibitors
Date Established
Date of Entry
Revision Date
Histone Deacetylases Preferred
Histone Deacetylase Complexes Narrower
Class I Histone Deacetylases Narrower
Class II Histone Deacetylases Narrower
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