MeSH Browser

MeSH Heading: Histone Deacetylases
Tree Number(s): D08.811.277.087.520
Unique ID: D006655
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D006655
Scope Note: Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of HISTONES. The enzyme family can be divided into at least three structurally-defined subclasses. Class I and class II deacetylases utilize a zinc-dependent mechanism. The sirtuin histone deacetylases belong to class III and are NAD-dependent enzymes.
Entry Term(s): Class I Histone Deacetylases; Class II Histone Deacetylases; HDAC Proteins; Histone Deacetylase; Histone Deacetylase Complexes
Related Numbers: EC 3.5.1.98
Previous Indexing: Acetic Acids (1971-1974); Amidohydrolases (1971-1974); Histones (1971-1974)
Public MeSH Note: 2003; see HISTONE DEACETYLASE 1991-2002; see AMIDOHYDROLASES 1975-1990
History Note: 2003; use AMIDOHYDROLASES 1975-1990
Entry Combination: antagonists & inhibitors:Histone Deacetylase Inhibitors
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2009/07/06

Entry Combination: antagonists & inhibitors:Histone Deacetylase Inhibitors
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0010420
Related Numbers: EC 3.5.1.98
Scope Note: Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of HISTONES. The enzyme family can be divided into at least three structurally-defined subclasses. Class I and class II deacetylases utilize a zinc-dependent mechanism. The sirtuin histone deacetylases belong to class III and are NAD-dependent enzymes.
Terms: Histone Deacetylases Preferred Term
Term UI T483423
Date02/25/2002
LexicalTag NON
ThesaurusID NLM (2003); HDAC Proteins
Term UI T485905
Date03/14/2002
LexicalTag ABX
ThesaurusID NLM (2003); Histone Deacetylase
Term UI T020050
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1975)

Histone Deacetylases MeSH Descriptor Data 2025