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Histone Deacetylase 6 MeSH Descriptor Data 2022


MeSH Heading
Histone Deacetylase 6
Tree Number(s)
D08.811.277.087.520.350
Unique ID
D000073864
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000073864
Scope Note
A class II histone deacetylase that removes acetyl groups from N-terminal LYSINES of HISTONE H2A; HISTONE H2B; HISTONE H3; and HISTONE H4. It plays a critical role in EPIGENETIC REPRESSION and regulation of GENETIC TRANSCRIPTION, as well as CELL MOTILITY through deacetylation of TUBULIN. It also targets misfolded proteins for clearance by AUTOPHAGY when MOLECULAR CHAPERONE-mediated folding is overwhelmed.
Registry Number
EC 3.5.1.98
Previous Indexing
Histone Deacetylases (2001-2017)
Public MeSH Note
2018
History Note
2018
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2017/01/17
Histone Deacetylase 6 Preferred
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