MeSH Browser

MeSH Heading: Histone Deacetylase Inhibitors
Tree Number(s): D27.505.519.389.360
Unique ID: D056572
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D056572
Scope Note: Compounds that inhibit HISTONE DEACETYLASES. This class of drugs may influence gene expression by increasing the level of acetylated HISTONES in specific CHROMATIN domains.
Entry Term(s): HDAC Inhibitor; HDAC Inhibitors; Histone Deacetylase Inhibitor
Previous Indexing: Histone Deacetylases/antagonists & inhibitors (1978-2009)
Public MeSH Note: 2010
History Note: 2010
Date Established: 2010/01/01
Date of Entry: 2009/07/06
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0527853
Scope Note: Compounds that inhibit HISTONE DEACETYLASES. This class of drugs may influence gene expression by increasing the level of acetylated HISTONES in specific CHROMATIN domains.
Terms: Histone Deacetylase Inhibitors Preferred Term
Term UI T732104
Date12/19/2008
LexicalTag NON
ThesaurusID NLM (2010); HDAC Inhibitor
Term UI T000999737
Date11/29/2019
LexicalTag NON
ThesaurusID NLM (2021); HDAC Inhibitors
Term UI T732105
Date12/19/2008
LexicalTag ABX
ThesaurusID NLM (2010); Histone Deacetylase Inhibitor
Term UI T732106
Date12/19/2008
LexicalTag NON
ThesaurusID NLM (2010)

Histone Deacetylase Inhibitors MeSH Descriptor Data 2025