MeSH Browser

MeSH Heading: Folic Acid Antagonists
Tree Number(s): D27.505.519.389.350
Unique ID: D005493
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D005493
Scope Note: Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033)
Entry Version: FOLIC ACID ANTAG
Entry Term(s): Antifolate; Antifolates; Dihydrofolate Reductase Inhibitor; Dihydrofolate Reductase Inhibitors; Folic Acid Antagonist; Folic Acid Metabolism Inhibitors
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2021/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

economics (EC)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

urine (UR)

Concept UI: M0008662
Scope Note: Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033)
Terms: Folic Acid Antagonists Preferred Term
Term UI T016718
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1966); Folic Acid Antagonist
Term UI T001089577
Date10/07/2020
LexicalTag NON
ThesaurusID NLM (2022); Antifolate
Term UI T001089578
Date10/07/2020
LexicalTag NON
ThesaurusID NLM (2022); Dihydrofolate Reductase Inhibitor
Term UI T001089579
Date10/07/2020
LexicalTag NON
ThesaurusID NLM (2022); Antifolates
Term UI T016719
Date12/06/1994
LexicalTag NON
ThesaurusID NLM (1996); Dihydrofolate Reductase Inhibitors
Term UI T848605
Date08/29/2013
LexicalTag NON
ThesaurusID NLM (2015)

Folic Acid Antagonists MeSH Descriptor Data 2025