Toggle navigation
Search
Tree View
MeSH on Demand
MeSH 2024
About
Suggestions
Contact Us
Gamma Secretase Inhibitors and Modulators
MeSH Descriptor Data 2025
Details
Qualifiers
MeSH Tree Structures
Concepts
MeSH Heading
Gamma Secretase Inhibitors and Modulators
Tree Number(s)
D27.505.519.389.315
Unique ID
D000091062
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000091062
Scope Note
Agents that suppress
GAMMA-SECRETASE
by inhibiting or modulating its activities. Targeted enzymatic activities include its involvement in accumulation of toxic
AMYLOID BETA-PEPTIDES
(e.g., Aβ42) in
ALZHEIMER DISEASE
and activation of
NOTCH RECEPTOR
mediated
SIGNAL PATHWAYS
in certain cancer types.
Entry Term(s)
GS Inhibitors
GS Inhibitors and Modulators
GS Modulators
Gamma Secretase Inhibitors
Gamma Secretase Modulators
Previous Indexing
Amyloid Precursor Protein Secretases (1995-2021)
Public MeSH Note
2022
History Note
2022
Date Established
2022/01/01
Date of Entry
2021/07/09
Revision Date
2021/06/30
Allowable Qualifiers
administration & dosage (AD)
adverse effects (AE)
analysis (AN)
blood (BL)
cerebrospinal fluid (CF)
chemical synthesis (CS)
chemistry (CH)
classification (CL)
economics (EC)
history (HI)
immunology (IM)
isolation & purification (IP)
metabolism (ME)
pharmacokinetics (PK)
pharmacology (PD)
poisoning (PO)
radiation effects (RE)
standards (ST)
supply & distribution (SD)
therapeutic use (TU)
toxicity (TO)
urine (UR)
Chemical Actions and Uses [D27]
Pharmacologic Actions [D27.505]
Molecular Mechanisms of Pharmacological Action [D27.505.519]
Enzyme Inhibitors [D27.505.519.389]
5-Lipoxygenase-Activating Protein Inhibitors [D27.505.519.389.086]
Acetaldehyde Dehydrogenase Inhibitors [D27.505.519.389.089]
Adenosine Deaminase Inhibitors [D27.505.519.389.092]
Adenylyl Cyclase Inhibitors [D27.505.519.389.108]
Aromatic Amino Acid Decarboxylase Inhibitors [D27.505.519.389.124]
Calcineurin Inhibitors [D27.505.519.389.174]
Carbonic Anhydrase Inhibitors [D27.505.519.389.200]
Catechol O-Methyltransferase Inhibitors [D27.505.519.389.237]
Cholinesterase Inhibitors [D27.505.519.389.275]
Cyclooxygenase Inhibitors [D27.505.519.389.310]
Gamma Secretase Inhibitors and Modulators [D27.505.519.389.315]
Glycoside Hydrolase Inhibitors [D27.505.519.389.320]
Cytochrome P-450 Enzyme Inhibitors [D27.505.519.389.335]
Folic Acid Antagonists [D27.505.519.389.350]
Histone Deacetylase Inhibitors [D27.505.519.389.360]
Hydroxymethylglutaryl-CoA Reductase Inhibitors [D27.505.519.389.370]
Integrase Inhibitors [D27.505.519.389.375]
beta-Lactamase Inhibitors [D27.505.519.389.400]
Lipoxygenase Inhibitors [D27.505.519.389.480]
Monoamine Oxidase Inhibitors [D27.505.519.389.616]
Nucleic Acid Synthesis Inhibitors [D27.505.519.389.675]
Ornithine Decarboxylase Inhibitors [D27.505.519.389.705]
Phosphodiesterase Inhibitors [D27.505.519.389.735]
Phosphoinositide-3 Kinase Inhibitors [D27.505.519.389.736]
Phospholipase A2 Inhibitors [D27.505.519.389.737]
Poly(ADP-ribose) Polymerase Inhibitors [D27.505.519.389.739]
Prolyl-Hydroxylase Inhibitors [D27.505.519.389.740]
Protease Inhibitors [D27.505.519.389.745]
Protein Kinase Inhibitors [D27.505.519.389.755]
Protein Synthesis Inhibitors [D27.505.519.389.760]
Proton Pump Inhibitors [D27.505.519.389.848]
Steroid Synthesis Inhibitors [D27.505.519.389.870]
Topoisomerase Inhibitors [D27.505.519.389.892]
Uncoupling Agents [D27.505.519.389.936]
Expand All
Collapse All
Gamma Secretase Inhibitors and Modulators
Preferred
Concept UI
M000747845
Scope Note
Agents that suppress
GAMMA-SECRETASE
by inhibiting or modulating its activities. Targeted enzymatic activities include its involvement in accumulation of toxic
AMYLOID BETA-PEPTIDES
(e.g., Aβ42) in
ALZHEIMER DISEASE
and activation of
NOTCH RECEPTOR
mediated
SIGNAL PATHWAYS
in certain cancer types.
Terms
Gamma Secretase Inhibitors and Modulators
Preferred Term
Term UI
T001106032
Date
05/07/2021
LexicalTag
NON
ThesaurusID
NLM (2022)
GS Inhibitors and Modulators
Term UI
T001106315
Date
05/13/2021
LexicalTag
NON
ThesaurusID
NLM (2022)
Gamma Secretase Inhibitors
Narrower
Concept UI
M000747846
Terms
Gamma Secretase Inhibitors
Preferred Term
Term UI
T001106033
Date
05/07/2021
LexicalTag
NON
ThesaurusID
NLM (2022)
GS Inhibitors
Term UI
T001106313
Date
05/13/2021
LexicalTag
NON
ThesaurusID
NLM (2022)
Gamma Secretase Modulators
Narrower
Concept UI
M000747847
Terms
Gamma Secretase Modulators
Preferred Term
Term UI
T001106034
Date
05/07/2021
LexicalTag
NON
ThesaurusID
NLM (2022)
GS Modulators
Term UI
T001106314
Date
05/13/2021
LexicalTag
NON
ThesaurusID
NLM (2022)
page delivered in 0.131s