Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

NLM Logo

Gamma Secretase Inhibitors and Modulators MeSH Descriptor Data 2026


MeSH Heading
Gamma Secretase Inhibitors and Modulators
Tree Number(s)
D27.505.519.389.315
Unique ID
D000091062
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000091062
Scope Note
Agents that suppress GAMMA-SECRETASE by inhibiting or modulating its activities. Targeted enzymatic activities include its involvement in accumulation of toxic AMYLOID BETA-PEPTIDES (e.g., Aβ42) in ALZHEIMER DISEASE and activation of NOTCH RECEPTOR mediated SIGNAL PATHWAYS in certain cancer types.
Entry Term(s)
GS Inhibitors
GS Inhibitors and Modulators
GS Modulators
Gamma Secretase Inhibitors
Gamma Secretase Modulators
Registry Numbers
0
Previous Indexing
Amyloid Precursor Protein Secretases (1995-2021)
Public MeSH Note
2022
History Note
2022
Date Introduced
2022/01/01
Last Updated
2022/01/01
Gamma Secretase Inhibitors and Modulators Preferred
Gamma Secretase Inhibitors Narrower
Gamma Secretase Modulators Narrower
page delivered in 0.169s