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Signal Transduction MeSH Descriptor Data 2023

MeSH Heading
Signal Transduction
Tree Number(s)
Unique ID
RDF Unique Identifier
Scope Note
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Entry Term(s)
Cell Signaling
Receptor Mediated Signal Transduction
Receptor-Mediated Signal Transduction
Signal Pathways
Signal Transduction Pathways
Signal Transduction Systems
NLM Classification #
QU 375
Previous Indexing
Membrane Potentials (1977-1988)
specific compounds/physiology (1977-1988)
See Also
Ion Channels
Public MeSH Note
History Note
Date Established
Date of Entry
Revision Date
Signal Transduction Preferred
Receptor-Mediated Signal Transduction Narrower
Signal Pathways Narrower
Signal Transduction Pathways Narrower
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