MeSH Browser

MeSH Heading: Signal Transduction
Tree Number(s): G02.111.820; G04.835
Unique ID: D015398
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015398
Scope Note: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Entry Term(s): Cell Signaling; Receptor Mediated Signal Transduction; Receptor-Mediated Signal Transduction; Signal Pathways; Signal Transduction Pathways; Signal Transduction Systems
NLM Classification #: QU 375
Previous Indexing: Membrane Potentials (1977-1988); specific compounds/physiology (1977-1988)
See Also: Ion Channels
Public MeSH Note: 89
History Note: 89
Date Established: 1989/01/01
Date of Entry: 1988/06/06
Revision Date: 2019/07/05

Allowable Qualifiers: drug effects (DE)

genetics (GE)

immunology (IM)

physiology (PH)

radiation effects (RE)

Chemical Phenomena [G02]
- Biochemical Phenomena [G02.111]

Cell Physiological Phenomena [G04]

Signal Transduction Preferred

Concept UI: M0023729
Scope Note: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Terms: Signal Transduction Preferred Term
Term UI T045414
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1989); Cell Signaling
Term UI T000959480
Date05/31/2019
LexicalTag NON
ThesaurusID NLM (2020); Signal Transduction Systems
Term UI T045415
Date06/06/1988
LexicalTag NON
ThesaurusID UNK (19XX)

Receptor-Mediated Signal Transduction Narrower

Signal Pathways Narrower

Signal Transduction Pathways Narrower

Signal Transduction MeSH Descriptor Data 2025