MeSH Browser

MeSH Heading: MAP Kinase Signaling System
Tree Number(s): G02.111.820.560; G03.493.560; G04.835.560
Unique ID: D020935
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D020935
Scope Note: An intracellular signaling system involving the mitogen-activated protein kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.
Entry Term(s): ERK Pathway; ERK Signal Tranduction Pathway; ERK1 and ERK2 Pathway; ERK1-2 Pathway; JNK Pathway; JNK Signaling Pathway; MAP Kinase Cascade; MAP Kinase Module; MAP Kinase Modules; MAP Kinase Signaling Cascade; MAP Kinase Signaling Cascades; MAP Kinase Signaling Pathway; MAP Kinase Signaling Pathways; MEK-ERK Pathway; p38 Kinase Pathway; p38 Kinase Signaling Pathway
Previous Indexing: Ca(2+)-Calmodulin Dependent Protein Kinase (1994-1999); Protein Kinases (1989-1999); Protein-Serine-Threonine Kinases (1993-1999); Protein-Tyrosine Kinase (1989-1999)
See Also: MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases
Public MeSH Note: 2000
History Note: 2000
Date Established: 2000/01/01
Date of Entry: 1999/11/05
Revision Date: 2022/06/14

Concept UI: M0331442
Terms: MAP Kinase Cascade Preferred Term
Term UI T361647
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); MAP Kinase Modules
Term UI T361632
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); MAP Kinase Signaling Cascades
Term UI T361633
Date10/12/1999
LexicalTag NON
ThesaurusID NLM (2000); MAP Kinase Module
Term UI T001089281
Date09/30/2020
LexicalTag NON
ThesaurusID NLM (2022); MAP Kinase Signaling Cascade
Term UI T001089282
Date09/30/2020
LexicalTag NON
ThesaurusID NLM (2022)

MAP Kinase Signaling Pathways Related

ERK1-2 Pathway Related

ERK Signal Tranduction Pathway Narrower

MEK-ERK Pathway Narrower

JNK Pathway Narrower

p38 Kinase Pathway Narrower

MAP Kinase Signaling System MeSH Descriptor Data 2025