MeSH Browser

MeSH Heading: Cellular Senescence
Tree Number(s): G04.043; G07.345.124.130
Unique ID: D016922
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D016922
Annotation: not for micro-organisms
Scope Note: Process by which cells irreversibly stop dividing and enter a state of permanent growth arrest without undergoing CELL DEATH. Senescence can be induced by DNA DAMAGE or other cellular stresses, such as OXIDATIVE STRESS.
Entry Term(s): Aging, Cell; Cell Ageing; Cell Aging; Cell Senescence; Cellular Ageing; Cellular Aging; Replicative Senescence; Senescence, Cellular; Senescence, Replicative
Previous Indexing: Cell Survival (1977-1991); Erythrocyte Aging (1967-1991)
See Also: Cell Death; Plant Senescence
Public MeSH Note: 2018; see CELL AGING 1992-2017; see CELL SURVIVAL 1977-1991; for CELL SENESCENCE and SENESCENCE, CELLULAR see CELL SURVIVAL 1991
History Note: 2018 (1992); use CELL SURVIVAL 1977-1991
Date Established: 1992/01/01
Date of Entry: 1991/05/30
Revision Date: 2021/07/07

Concept UI: M000630817
Scope Note: Cellular senescence during AGING or due to extended passages of normal cells in culture and that is triggered by the DNA damage-response to TELOMERE SHORTENING or by repeated exposure to stress signals.
Terms: Cell Aging Preferred Term
Term UI T050665
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1992); Cellular Ageing
Term UI T000925302
Date05/24/2017
LexicalTag NON
ThesaurusID NLM (2018); Aging, Cell
Term UI T050664
Date04/17/1991
LexicalTag NON
ThesaurusID NLM (1992); Cell Ageing
Term UI T000924771
Date05/17/2017
LexicalTag NON
ThesaurusID NLM (2018); Cellular Aging
Term UI T050668
Date05/14/1991
LexicalTag NON
ThesaurusID NLM (1992); Replicative Senescence
Term UI T050669
Date09/11/1997
LexicalTag NON
ThesaurusID NLM (1999); Senescence, Replicative
Term UI T050670
Date09/11/1997
LexicalTag NON
ThesaurusID NLM (1999)

Cellular Senescence MeSH Descriptor Data 2025