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Protein Aggregation, Pathological
MeSH Descriptor Data 2025
Details
Qualifiers
MeSH Tree Structures
Concepts
MeSH Heading
Protein Aggregation, Pathological
Tree Number(s)
C23.550.770
G02.111.675
Unique ID
D066263
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D066263
Scope Note
A biochemical phenomenon in which misfolded proteins aggregate either intra- or extracellularly. Triggered by factors such as
MUTATION
;
POST-TRANSLATIONAL MODIFICATIONS
, and environmental stress, it is generally associated with
ALZHEIMER DISEASE
;
PARKINSON DISEASE
;
HUNTINGTON DISEASE
; and
TYPE 2 DIABETES MELLITUS
.
See Also
Protein Aggregates
Public MeSH Note
2015
History Note
2015
Date Established
2015/01/01
Date of Entry
2014/06/26
Revision Date
2020/02/05
Allowable Qualifiers
blood (BL)
cerebrospinal fluid (CF)
chemically induced (CI)
classification (CL)
complications (CO)
congenital (CN)
diagnosis (DI)
diagnostic imaging (DG)
diet therapy (DH)
drug therapy (DT)
economics (EC)
embryology (EM)
enzymology (EN)
epidemiology (EP)
ethnology (EH)
etiology (ET)
genetics (GE)
history (HI)
immunology (IM)
metabolism (ME)
microbiology (MI)
mortality (MO)
nursing (NU)
parasitology (PS)
pathology (PA)
physiopathology (PP)
prevention & control (PC)
psychology (PX)
radiotherapy (RT)
rehabilitation (RH)
surgery (SU)
therapy (TH)
urine (UR)
veterinary (VE)
virology (VI)
Pathological Conditions, Signs and Symptoms [C23]
Pathologic Processes [C23.550]
Acantholysis [C23.550.035]
Arrhythmias, Cardiac [C23.550.073]
Ascites [C23.550.081]
Atrial Remodeling [C23.550.113]
Azotemia [C23.550.145]
Cardiotoxicity [C23.550.161]
Channelopathies [C23.550.177]
Chromosome Aberrations [C23.550.210]
Death [C23.550.260]
Dehydration [C23.550.274]
Delayed Graft Function [C23.550.277]
Disease [C23.550.288]
Disease Attributes [C23.550.291]
Dysbiosis [C23.550.308]
Emphysema [C23.550.325]
Extravasation of Diagnostic and Therapeutic Materials [C23.550.340]
Femoracetabular Impingement [C23.550.347]
Fibrosis [C23.550.355]
Frailty [C23.550.359]
Genomic Instability [C23.550.362]
Gliosis [C23.550.369]
Granuloma [C23.550.382]
Granulomatosis, Orofacial [C23.550.384]
Growth Disorders [C23.550.393]
Hemolysis [C23.550.403]
Hemorrhage [C23.550.414]
Hyperammonemia [C23.550.421]
Hyperamylasemia [C23.550.425]
Hyperbilirubinemia [C23.550.429]
Hyperplasia [C23.550.444]
Hyperuricemia [C23.550.449]
Hypovolemia [C23.550.455]
Inflammation [C23.550.470]
Intraoperative Complications [C23.550.505]
Ischemia [C23.550.513]
Leukoaraiosis [C23.550.522]
Leukocytosis [C23.550.526]
Lithiasis [C23.550.537]
Long Term Adverse Effects [C23.550.543]
Malacoplakia [C23.550.548]
Menstruation Disturbances [C23.550.568]
Metaplasia [C23.550.589]
Muscle Weakness [C23.550.695]
Myotoxicity [C23.550.706]
Necrosis [C23.550.717]
Neointima [C23.550.722]
Neoplastic Processes [C23.550.727]
Nerve Degeneration [C23.550.737]
Ochronosis [C23.550.744]
Ossification, Heterotopic [C23.550.751]
Ototoxicity [C23.550.753]
Pigmentation Disorders [C23.550.755]
Polydipsia [C23.550.759]
Postoperative Complications [C23.550.767]
Protein Aggregation, Pathological [C23.550.770]
Respiratory Aspiration [C23.550.773]
Retropneumoperitoneum [C23.550.794]
Sclerosis [C23.550.823]
Shock [C23.550.835]
Teratogenesis [C23.550.863]
Toxic Optic Neuropathy [C23.550.877]
Ulcer [C23.550.891]
Vascular Remodeling [C23.550.918]
Yang Deficiency [C23.550.945]
Yin Deficiency [C23.550.972]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Acid-Base Equilibrium [G02.111.007]
Acylation [G02.111.012]
Aerobiosis [G02.111.017]
Agglutination [G02.111.026]
Alkylation [G02.111.035]
Allosteric Regulation [G02.111.044]
Amination [G02.111.053]
Anaerobiosis [G02.111.062]
Autotrophic Processes [G02.111.071]
Base Composition [G02.111.080]
Binding, Competitive [G02.111.084]
Biocatalysis [G02.111.086]
Biomineralization [G02.111.092]
Biosynthetic Pathways [G02.111.098]
Biotinylation [G02.111.109]
Body Composition [G02.111.130]
Brain Chemistry [G02.111.150]
Carbohydrate Metabolism [G02.111.158]
Citric Acid Cycle [G02.111.165]
Cyclization [G02.111.180]
Dealkylation [G02.111.188]
Deamination [G02.111.192]
Decarboxylation [G02.111.195]
DNA Cleavage [G02.111.210]
DNA Methylation [G02.111.218]
DNA Repair [G02.111.222]
DNA Replication [G02.111.225]
Down-Regulation [G02.111.240]
Electron Transport [G02.111.248]
Energy Transfer [G02.111.255]
Enzyme Activation [G02.111.263]
Esterification [G02.111.270]
Halogenation [G02.111.323]
Heterotrophic Processes [G02.111.375]
Hydrogenation [G02.111.380]
Hydroxylation [G02.111.385]
Kinetics [G02.111.490]
Lipid Peroxidation [G02.111.515]
Lipogenesis [G02.111.528]
Lipolysis [G02.111.534]
Lipoylation [G02.111.540]
Melanogenesis [G02.111.545]
Membrane Fluidity [G02.111.550]
Molecular Mimicry [G02.111.560]
Molecular Structure [G02.111.570]
Nitrogen Cycle [G02.111.587]
Nitrosation [G02.111.595]
Nucleic Acid Denaturation [G02.111.603]
Nucleic Acid Hybridization [G02.111.611]
Nucleic Acid Renaturation [G02.111.619]
Osmoregulation [G02.111.635]
Osmosis [G02.111.655]
Peptide Biosynthesis [G02.111.660]
Phosphorylation [G02.111.665]
Phototrophic Processes [G02.111.669]
Prenylation [G02.111.672]
Protein Aggregation, Pathological [G02.111.675]
Protein Binding [G02.111.679]
Protein Folding [G02.111.688]
Protein Modification, Translational [G02.111.691]
Protein Multimerization [G02.111.694]
Protein Stability [G02.111.700]
Proteolysis [G02.111.720]
Proteostasis [G02.111.730]
RNA Cleavage [G02.111.740]
RNA Folding [G02.111.750]
RNA Processing, Post-Transcriptional [G02.111.760]
RNA Replication [G02.111.770]
RNA Stability [G02.111.780]
Sequence Homology [G02.111.810]
Signal Transduction [G02.111.820]
Structure-Activity Relationship [G02.111.830]
Substrate Cycling [G02.111.833]
Substrate Specificity [G02.111.835]
Transcription, Genetic [G02.111.873]
Up-Regulation [G02.111.905]
Expand All
Collapse All
Protein Aggregation, Pathological
Preferred
Concept UI
M0593510
Scope Note
A biochemical phenomenon in which misfolded proteins aggregate either intra- or extracellularly. Triggered by factors such as
MUTATION
;
POST-TRANSLATIONAL MODIFICATIONS
, and environmental stress, it is generally associated with
ALZHEIMER DISEASE
;
PARKINSON DISEASE
;
HUNTINGTON DISEASE
; and
TYPE 2 DIABETES MELLITUS
.
Terms
Protein Aggregation, Pathological
Preferred Term
Term UI
T859698
Date
05/14/2014
LexicalTag
NON
ThesaurusID
NLM (2015)
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