MeSH Browser

MeSH Heading: Substrate Cycling
Tree Number(s): G02.111.833; G03.295.835
Unique ID: D015219
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D015219
Annotation: restricted to enzyme activity; almost never IM; coord NIM with specific enzyme (IM)
Scope Note: A set of opposing, nonequilibrium reactions catalyzed by different enzymes which act simultaneously, with at least one of the reactions driven by ATP hydrolysis. The results of the cycle are that ATP energy is depleted, heat is produced and no net substrate-to-product conversion is achieved. Examples of substrate cycling are cycling of gluconeogenesis and glycolysis pathways and cycling of the triglycerides and fatty acid pathways. Rates of substrate cycling may be increased many-fold in association with hypermetabolic states resulting from severe burns, cold exposure, hyperthyroidism, or acute exercise.
Entry Term(s): Futile Cycles; Futile Cycling; Futile Substrate Cycles; Futile Substrate Cycling
Previous Indexing: Energy Metabolism (1975-1988); specific substance/metabolism (1975-1988)
Public MeSH Note: 89
History Note: 89
Date Established: 1989/01/01
Date of Entry: 1988/05/11
Revision Date: 2016/07/01

Concept UI: M0023382
Terms: Futile Cycles Preferred Term
Term UI T044504
Date05/11/1988
LexicalTag NON
ThesaurusID UNK (19XX); Futile Cycling
Term UI T044505
Date05/11/1988
LexicalTag NON
ThesaurusID UNK (19XX); Futile Substrate Cycles
Term UI T044506
Date05/11/1988
LexicalTag NON
ThesaurusID UNK (19XX); Futile Substrate Cycling
Term UI T044507
Date05/11/1988
LexicalTag NON
ThesaurusID UNK (19XX)

Substrate Cycling MeSH Descriptor Data 2025