MeSH Browser

MeSH Heading: Receptors, Notch
Tree Number(s): D12.776.543.750.725; D12.776.930.770
Unique ID: D051880
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D051880
Scope Note: A family of conserved cell surface receptors that contain EPIDERMAL GROWTH FACTOR repeats in their extracellular domain and ANKYRIN REPEATS in their cytoplasmic domains. The cytoplasmic domains are released upon ligand binding and translocate to the CELL NUCLEUS, where they act as transcription factors.
Entry Term(s): Notch Protein; Notch Proteins; Notch Receptor; Notch Receptors
Public MeSH Note: 2006; RECEPTORS, NOTCH was indexed under MEMBRANE PROTEINS 1990-2005, & under INSECT HORMONES 1990-1995
History Note: 2006(1990)
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2020/05/27

Allowable Qualifiers: administration & dosage (AD)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

physiology (PH)

radiation effects (RE)

therapeutic use (TU)

ultrastructure (UL)

Concept UI: M0176572
Scope Note: A family of conserved cell surface receptors that contain EPIDERMAL GROWTH FACTOR repeats in their extracellular domain and ANKYRIN REPEATS in their cytoplasmic domains. The cytoplasmic domains are released upon ligand binding and translocate to the CELL NUCLEUS, where they act as transcription factors.
Terms: Receptors, Notch Preferred Term
Term UI T633422
Date03/16/2005
LexicalTag NON
ThesaurusID NLM (2006); Notch Receptor
Term UI T000997439
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021); Notch Receptors
Term UI T589626
Date06/07/2004
LexicalTag NON
ThesaurusID NLM (2006); Notch Proteins
Term UI T633423
Date03/16/2005
LexicalTag NON
ThesaurusID NLM (2006); Notch Protein
Term UI T000997440
Date11/19/2019
LexicalTag NON
ThesaurusID NLM (2021)

Receptors, Notch MeSH Descriptor Data 2025