MeSH Browser

MeSH Heading: Elongin
Tree Number(s): D12.776.260.197; D12.776.930.215
Unique ID: D000075065
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000075065
Scope Note: A heterotrimeric protein complex composed of 110 kDa elongin A, 18 kDa elongin B, and 15 kDa elongin C subunits. It functions as a positive regulator of RNA POLYMERASE II, increasing its rate of transcriptional elongation by suppressing transient pausing along the DNA template. Elongin A is the transcriptionally active component; elongins B and C enhance its activity.
Entry Term(s): EloA Protein; EloB Protein; EloC Protein; Elongin A; Elongin B; Elongin C; Elongin Complex; SIII Elongation Factor; TF-SIII; Transcription Factor SIII
Registry Numbers: 0
Public MeSH Note: 2018; ELONGIN was indexed under TRANSCRIPTION FACTORS 1995-2017
History Note: 2018 (1995)
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/05/22

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000629054
Registry Numbers: 0
Scope Note: A heterotrimeric protein complex composed of 110 kDa elongin A, 18 kDa elongin B, and 15 kDa elongin C subunits. It functions as a positive regulator of RNA POLYMERASE II, increasing its rate of transcriptional elongation by suppressing transient pausing along the DNA template. Elongin A is the transcriptionally active component; elongins B and C enhance its activity.
Terms: Elongin Preferred Term
Term UI T000920285
Date03/29/2017
LexicalTag NON
ThesaurusID NLM (1995); Elongin Complex
Term UI T000920283
Date03/29/2017
LexicalTag NON
ThesaurusID NLM (2018); SIII Elongation Factor
Term UI T000920284
Date03/29/2017
LexicalTag ABX
ThesaurusID NLM (1994); Transcription Factor SIII
Term UI T000920287
Date03/29/2017
LexicalTag ABX
ThesaurusID NLM (1995); TF-SIII
Term UI T281361
Date01/01/1955
LexicalTag ABB
ThesaurusID NLM (1995)

Elongin MeSH Descriptor Data 2025