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Methyl-CpG-Binding Protein 2
MeSH Descriptor Data 2025
Details
Qualifiers
MeSH Tree Structures
Concepts
MeSH Heading
Methyl-CpG-Binding Protein 2
Tree Number(s)
D12.776.260.536
D12.776.660.235.550
D12.776.664.235.700
Unique ID
D051783
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D051783
Scope Note
A DNA-binding protein that interacts with methylated
CPG ISLANDS
. It plays a role in repressing
GENETIC TRANSCRIPTION
and is frequently mutated in
RETT SYNDROME
.
Entry Term(s)
MeCP2 Protein
See Also
Methyl CpG Binding Domain
Rett Syndrome
Public MeSH Note
2006; METHYL-CPG-BINDING PROTEIN 2 was indexed under CHROMOSOMAL PROTEINS, NON-HISTONE & DNA-BINDING PROTEINS & REPRESSOR PROTEINS 2005, & under TRANSCRIPTION FACTORS 1992-2004
History Note
2006(1992)
Date Established
2006/01/01
Date of Entry
2005/06/30
Revision Date
2015/11/24
Allowable Qualifiers
administration & dosage (AD)
adverse effects (AE)
agonists (AG)
analysis (AN)
antagonists & inhibitors (AI)
biosynthesis (BI)
blood (BL)
cerebrospinal fluid (CF)
chemical synthesis (CS)
chemistry (CH)
classification (CL)
deficiency (DF)
drug effects (DE)
economics (EC)
genetics (GE)
history (HI)
immunology (IM)
isolation & purification (IP)
metabolism (ME)
pharmacokinetics (PK)
pharmacology (PD)
physiology (PH)
poisoning (PO)
radiation effects (RE)
standards (ST)
supply & distribution (SD)
therapeutic use (TU)
toxicity (TO)
ultrastructure (UL)
urine (UR)
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Adenovirus E2 Proteins [D12.776.260.060]
Basic Helix-Loop-Helix Transcription Factors [D12.776.260.103]
Basic-Leucine Zipper Transcription Factors [D12.776.260.108]
Butyrate Response Factor 1 [D12.776.260.114]
CCCTC-Binding Factor [D12.776.260.120]
Centromere Protein A [D12.776.260.123]
Centromere Protein B [D12.776.260.125]
Early Growth Response Transcription Factors [D12.776.260.158]
Elongin [D12.776.260.197]
Erythroid-Specific DNA-Binding Factors [D12.776.260.235]
Factor For Inversion Stimulation Protein [D12.776.260.246]
G-Box Binding Factors [D12.776.260.254]
GATA Transcription Factors [D12.776.260.257]
Heat Shock Transcription Factors [D12.776.260.260]
Hepatocyte Nuclear Factors [D12.776.260.262]
Heterogeneous-Nuclear Ribonucleoprotein K [D12.776.260.268]
HMGA Proteins [D12.776.260.312]
HMGB Proteins [D12.776.260.356]
Homeodomain Proteins [D12.776.260.400]
I-kappa B Proteins [D12.776.260.420]
Immunoglobulin J Recombination Signal Sequence-Binding Protein [D12.776.260.457]
Integration Host Factors [D12.776.260.495]
Interferon Regulatory Factors [D12.776.260.504]
Interferon-Stimulated Gene Factor 3 [D12.776.260.513]
Kruppel-Like Transcription Factors [D12.776.260.522]
Ku Autoantigen [D12.776.260.525]
Leucine-Responsive Regulatory Protein [D12.776.260.527]
LIM-Homeodomain Proteins [D12.776.260.529]
Liver X Receptors [D12.776.260.531]
Matrix Attachment Region Binding Proteins [D12.776.260.532]
MDS1 and EVI1 Complex Locus Protein [D12.776.260.534]
Methyl-CpG-Binding Protein 2 [D12.776.260.536]
Minichromosome Maintenance 1 Protein [D12.776.260.538]
MRE11 Homologue Protein [D12.776.260.539]
MutL Proteins [D12.776.260.540]
MutS Proteins [D12.776.260.556]
Myeloid-Lymphoid Leukemia Protein [D12.776.260.560]
NF-kappa B [D12.776.260.600]
NFI Transcription Factors [D12.776.260.605]
Nuclear Respiratory Factors [D12.776.260.615]
Nucleobindins [D12.776.260.623]
Oncogene Protein p55(v-myc) [D12.776.260.630]
Origin Recognition Complex [D12.776.260.640]
Orphan Nuclear Receptors [D12.776.260.643]
Paired Box Transcription Factors [D12.776.260.645]
Peptidyl-Prolyl Cis-Trans Isomerase NIMA-Interacting 4 [D12.776.260.650]
POU Domain Factors [D12.776.260.655]
Proto-Oncogene Proteins c-bcl-6 [D12.776.260.660]
Proto-Oncogene Proteins c-ets [D12.776.260.665]
Proto-Oncogene Proteins c-myb [D12.776.260.675]
Proto-Oncogene Proteins c-rel [D12.776.260.682]
Proto-Oncogene Proteins c-sis [D12.776.260.690]
PTB-Associated Splicing Factor [D12.776.260.693]
Rad51 Recombinase [D12.776.260.695]
Rad52 DNA Repair and Recombination Protein [D12.776.260.696]
Replication Protein A [D12.776.260.700]
Replication Protein C [D12.776.260.702]
Repressor Proteins [D12.776.260.703]
Retinoblastoma Protein [D12.776.260.704]
Smad Proteins [D12.776.260.713]
SMARCB1 Protein [D12.776.260.716]
SOX Transcription Factors [D12.776.260.719]
T-Box Domain Proteins [D12.776.260.725]
TCF Transcription Factors [D12.776.260.730]
TEA Domain Transcription Factors [D12.776.260.733]
Telomere-Binding Proteins [D12.776.260.735]
Toll-Like Receptor 9 [D12.776.260.750]
Trans-Activators [D12.776.260.755]
Transcription Factor AP-2 [D12.776.260.760]
Transcription Factor MTF-1 [D12.776.260.768]
Transcription Factors, General [D12.776.260.775]
Tristetraprolin [D12.776.260.790]
Tumor Suppressor p53-Binding Protein 1 [D12.776.260.805]
Tumor Suppressor Protein p53 [D12.776.260.820]
Tumor Protein p73 [D12.776.260.885]
Winged-Helix Transcription Factors [D12.776.260.950]
X-ray Repair Cross Complementing Protein 1 [D12.776.260.963]
Xeroderma Pigmentosum Group A Protein [D12.776.260.975]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Nuclear Proteins [D12.776.660]
Chromosomal Proteins, Non-Histone [D12.776.660.235]
Bromodomain Containing Proteins [D12.776.660.235.025]
CCCTC-Binding Factor [D12.776.660.235.050]
Centromere Protein A [D12.776.660.235.100]
Centromere Protein B [D12.776.660.235.199]
Chromobox Protein Homolog 5 [D12.776.660.235.300]
Cohesins [D12.776.660.235.350]
High Mobility Group Proteins [D12.776.660.235.400]
Minichromosome Maintenance Proteins [D12.776.660.235.500]
Methyl-CpG-Binding Protein 2 [D12.776.660.235.550]
Polycomb-Group Proteins [D12.776.660.235.600]
SMARCB1 Protein [D12.776.660.235.650]
Structural Maintenance of Chromosome Protein 1 [D12.776.660.235.675]
Telomere-Binding Proteins [D12.776.660.235.700]
Tumor Suppressor p53-Binding Protein 1 [D12.776.660.235.850]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Nucleoproteins [D12.776.664]
Chromosomal Proteins, Non-Histone [D12.776.664.235]
Bromodomain Containing Proteins [D12.776.664.235.025]
CCCTC-Binding Factor [D12.776.664.235.050]
Centromere Protein A [D12.776.664.235.100]
Centromere Protein B [D12.776.664.235.199]
Chromobox Protein Homolog 5 [D12.776.664.235.300]
Cohesins [D12.776.664.235.350]
High Mobility Group Proteins [D12.776.664.235.400]
Methyl-CpG-Binding Protein 2 [D12.776.664.235.700]
Minichromosome Maintenance Proteins [D12.776.664.235.750]
Polycomb-Group Proteins [D12.776.664.235.800]
SMARCB1 Protein [D12.776.664.235.900]
Structural Maintenance of Chromosome Protein 1 [D12.776.664.235.925]
Tumor Suppressor p53-Binding Protein 1 [D12.776.664.235.950]
Expand All
Collapse All
Methyl-CpG-Binding Protein 2
Preferred
Concept UI
M0208047
Scope Note
A DNA-binding protein that interacts with methylated
CPG ISLANDS
. It plays a role in repressing
GENETIC TRANSCRIPTION
and is frequently mutated in
RETT SYNDROME
.
Terms
Methyl-CpG-Binding Protein 2
Preferred Term
Term UI
T613684
Date
10/17/2004
LexicalTag
NON
ThesaurusID
NLM (2006)
MeCP2 Protein
Term UI
T238052
Date
01/01/1955
LexicalTag
ABX
ThesaurusID
NLM (2006)
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