MeSH Browser

MeSH Heading: Tumor Suppressor p53-Binding Protein 1
Tree Number(s): D12.776.260.805; D12.776.660.235.850; D12.776.664.235.950
Unique ID: D000071857
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071857
Scope Note: A nuclear and cytoplasmic protein that associates with KINETOCHORES and contains a C-terminal TUDOR DOMAIN. It plays a critical role in the cellular response to DNA DAMAGE and localizes to DOUBLE-STRAND DNA BREAKS. It may also function in M PHASE CELL CYCLE CHECKPOINTS and as an enhancer of TUMOR SUPPRESSOR PROTEIN P53-mediated transcriptional activation.
Entry Term(s): 53BP1 Protein; TP53BP1 Protein; Tumor Protein p53-Binding Protein, 1; p202 Protein
Previous Indexing: Chromosomal Proteins, Non-Histone (2005-2016); DNA-Binding Proteins (2005-2016); Intracellular Signaling Peptides and Proteins (2005-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/07/05

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000615636
Scope Note: A nuclear and cytoplasmic protein that associates with KINETOCHORES and contains a C-terminal TUDOR DOMAIN. It plays a critical role in the cellular response to DNA DAMAGE and localizes to DOUBLE-STRAND DNA BREAKS. It may also function in M PHASE CELL CYCLE CHECKPOINTS and as an enhancer of TUMOR SUPPRESSOR PROTEIN P53-mediated transcriptional activation.
Terms: Tumor Suppressor p53-Binding Protein 1 Preferred Term
Term UI T000896957
Date03/11/2016
LexicalTag NON
ThesaurusID NLM (2017); Tumor Protein p53-Binding Protein, 1
Term UI T000896958
Date03/11/2016
LexicalTag NON
ThesaurusID NLM (2017); 53BP1 Protein
Term UI T000896959
Date03/11/2016
LexicalTag ABX
ThesaurusID NLM (2017); p202 Protein
Term UI T000896960
Date03/11/2016
LexicalTag ABX
ThesaurusID NLM (2017); TP53BP1 Protein
Term UI T000896961
Date03/11/2016
LexicalTag ABX
ThesaurusID NLM (2017)

Tumor Suppressor p53-Binding Protein 1 MeSH Descriptor Data 2025