MeSH Browser

MeSH Heading: PTB-Associated Splicing Factor
Tree Number(s): D12.776.157.725.829.282; D12.776.260.693; D12.776.664.962.829.282
Unique ID: D000072670
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000072670
Scope Note: An RNA splicing factor that also binds DNA. It is essential for pre-mRNA spicing in the formation of early SPLICEOSOMES and catalytic step II. It binds specifically to polypyrimidine tracts in INTRONS and is involved in the regulation of ALTERNATIVE SPLICING by SIGNAL TRANSDUCTION PATHWAYS.
Entry Term(s): PSF Splicing Factor; Polypyrimidine Tract-Binding Protein-Associated Splicing Factor; SFPQ Protein; Splicing Factor Proline-Glutamine Rich Protein
See Also: Polypyrimidine Tract-Binding Protein
Public MeSH Note: 2017; PTB-ASSOCIATED SPLICING FACTOR was indexed under RNA-BINDING PROTEINS 1993-2016
History Note: 2017 (1993)
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/07/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

PTB-Associated Splicing Factor MeSH Descriptor Data 2025