MeSH Browser

MeSH Heading: Centromere Protein A
Tree Number(s): D12.776.157.687.173; D12.776.260.123; D12.776.660.235.100; D12.776.660.720.173; D12.776.664.235.100; D23.050.422.031
Unique ID: D000076247
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000076247
Scope Note: A 17 kDa, centromeric, poly(ADP)-ribose binding protein that is structurally similar to HISTONE H3 and localizes to NUCLEOSOMES within the CENTROMERE; specifically within the region that binds KINETOCHORES, where it replaces histone H3. It plays a critical role in recruiting kinetochore proteins and progression through MITOSIS, chromosome segregation, and CYTOKINESIS. It also binds sera from patients with some scleroderma-like AUTOIMMUNE DISEASES.
Entry Term(s): CENP-A Protein; CENPA Protein; Centromere Autoantigens 17K; Centromere Protein 17K
Public MeSH Note: 2018; CENTROMERE PROTEIN A was indexed under AUTOANTIGENS 1987-2017 and CHROMOSOMAL PROTEINS, NON-HISTONE 1990-2017; and under NUCLEOPROTEINS 1987-1989
History Note: 2018 (1987)
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/29

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0147022
Scope Note: A 17 kDa, centromeric, poly(ADP)-ribose binding protein that is structurally similar to HISTONE H3 and localizes to NUCLEOSOMES within the CENTROMERE; specifically within the region that binds KINETOCHORES, where it replaces histone H3. It plays a critical role in recruiting kinetochore proteins and progression through MITOSIS, chromosome segregation, and CYTOKINESIS. It also binds sera from patients with some scleroderma-like AUTOIMMUNE DISEASES.
Terms: Centromere Protein A Preferred Term
Term UI T000925903
Date06/01/2017
LexicalTag NON
ThesaurusID NLM (2000); CENP-A Protein
Term UI T000926824
Date06/13/2017
LexicalTag ABX
ThesaurusID NLM (2018); Centromere Autoantigens 17K
Term UI T000925904
Date06/01/2017
LexicalTag NON
ThesaurusID NLM (1987); Centromere Protein 17K
Term UI T000925905
Date06/01/2017
LexicalTag NON
ThesaurusID NLM (1987); CENPA Protein
Term UI T000925906
Date06/01/2017
LexicalTag ABX
ThesaurusID NLM (2018)

Centromere Protein A MeSH Descriptor Data 2025