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Nicotinamide-Nucleotide Adenylyltransferase MeSH Descriptor Data 2026
An enzyme that catalyzes reversibly the transfer of the adenylyl moiety of ATP to the phosphoryl group of NMN to form NAD+ and pyrophosphate. The enzyme is found predominantly in the nuclei and catalyzes the final reaction in the major pathway for the biosynthesis of NAD in mammals.
Entry Term(s)
ATP-NMN Adenylyltransferase
NAD Pyrophosphorylase
NMN Adenylyltransferase
Nicotinamide Mononucleotide Adenylyltransferase
Registry Numbers
EC 2.7.7.1
Related Numbers
9032-70-6
CAS Type 1 Name
ATP:nicotinamide-nucleotide adenylyltransferase
Previous Indexing
Adenosine Triphosphate (1966-1978)
Nicotinamide Mononucleotide (1973-1978)
Nucleotidyltransferases (1966-1978)
Transferases (1966-1967)
Public MeSH Note
98; see NMN ADENYLYLTRANSFERASE 1991-97; see NUCLEOTIDYLTRANSFERASES 1979-90
An enzyme that catalyzes reversibly the transfer of the adenylyl moiety of ATP to the phosphoryl group of NMN to form NAD+ and pyrophosphate. The enzyme is found predominantly in the nuclei and catalyzes the final reaction in the major pathway for the biosynthesis of NAD in mammals.