MeSH Browser

MeSH Heading: Tumor Suppressor Protein p53
Tree Number(s): D12.776.157.687.650; D12.776.260.820; D12.776.624.776.775; D12.776.660.720.650; D12.776.744.845
Unique ID: D016159
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D016159
Scope Note: Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
Entry Term(s): Cellular Tumor Antigen p53; Oncoprotein p53; TP53 Protein; TRP53 Protein; p53 Antigen; p53 Tumor Suppressor Protein; pp53 Phosphoprotein
Registry Numbers: 0
Previous Indexing: Neoplasm Proteins (1981-1989); Oncogene Products (1990); Phosphoproteins (1981-1990)
Public MeSH Note: 2005; see TP53 PROTEIN 1991-2005; TP53 PROTEIN was indexed under NERVE TISSUE PROTEINS & NEOPLASM PROTEINS 1992-1993
History Note: 2005(1991);
Date Established: 1991/01/01
Date of Entry: 1990/06/19
Revision Date: 2017/05/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0024670
Registry Numbers: 0
Scope Note: Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
Terms: Tumor Suppressor Protein p53 Preferred Term
Term UI T623135
Date12/10/2004
LexicalTag NON
ThesaurusID NLM (2006); p53 Antigen
Term UI T047975
Date01/31/1990
LexicalTag NON
ThesaurusID NLM (1991); TP53 Protein
Term UI T047979
Date12/22/1992
LexicalTag ABX
ThesaurusID NLM (1994); p53 Tumor Suppressor Protein
Term UI T629616
Date02/03/2005
LexicalTag NON
ThesaurusID NLM (2006); pp53 Phosphoprotein
Term UI T629619
Date02/03/2005
LexicalTag ABX
ThesaurusID NLM (2006); Cellular Tumor Antigen p53
Term UI T633724
Date03/18/2005
LexicalTag NON
ThesaurusID NLM (2006); Oncoprotein p53
Term UI T047974
Date01/31/1990
LexicalTag NON
ThesaurusID NLM (1991); TRP53 Protein
Term UI T636784
Date04/14/2005
LexicalTag ABX
ThesaurusID NLM (2006)

Tumor Suppressor Protein p53 MeSH Descriptor Data 2025