MeSH Browser

MeSH Heading: Von Hippel-Lindau Tumor Suppressor Protein
Tree Number(s): D08.811.464.938.750.875; D12.776.624.776.865
Unique ID: D051794
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D051794
Scope Note: A ubiquitin-protein ligase that mediates OXYGEN-dependent polyubiquitination of HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT. It is inactivated in VON HIPPEL-LINDAU SYNDROME.
Entry Term(s): VHL Tumor Suppressor Protein
Registry Numbers: EC 2.3.2.27
Public MeSH Note: 2006; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN was indexed under TUMOR SUPPRESSOR PROTEINS 2002-2005, under UBIQUITIN-PROTEIN LIGASES 2004-2005, under LIGASES 2002-3003, under PROTEINS 1995-2001, & under NUCLEAR PROTEINS 1995
History Note: 2006 (1995)
Entry Combination: deficiency:von Hippel-Lindau Disease
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2016/06/02

Entry Combination: deficiency:von Hippel-Lindau Disease
Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Von Hippel-Lindau Tumor Suppressor Protein MeSH Descriptor Data 2025