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Polycomb Repressive Complex 1
MeSH Descriptor Data 2025
Details
Qualifiers
MeSH Tree Structures
Concepts
MeSH Heading
Polycomb Repressive Complex 1
Tree Number(s)
D05.500.781.100
D08.811.464.938.750.280
D12.776.660.235.600.100
D12.776.664.235.800.100
D12.776.930.780.890.100
Unique ID
D063150
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D063150
Scope Note
A multisubunit polycomb protein complex with affinity for
CHROMATIN
that contains methylated
HISTONE H3
. It contains an E3 ubiquitin ligase activity that is specific for
HISTONE H2A
and works in conjunction with
POLYCOMB REPRESSIVE COMPLEX 2
to effect
EPIGENETIC REPRESSION
.
Previous Indexing
Repressor Proteins (1998-2012)
Transcription Factors (1997)
Public MeSH Note
2013
History Note
2013
Date Established
2013/01/01
Date of Entry
2012/07/03
Revision Date
2016/06/02
Allowable Qualifiers
administration & dosage (AD)
adverse effects (AE)
agonists (AG)
analysis (AN)
antagonists & inhibitors (AI)
biosynthesis (BI)
blood (BL)
cerebrospinal fluid (CF)
chemical synthesis (CS)
chemistry (CH)
classification (CL)
deficiency (DF)
drug effects (DE)
economics (EC)
genetics (GE)
history (HI)
immunology (IM)
isolation & purification (IP)
metabolism (ME)
pharmacokinetics (PK)
pharmacology (PD)
physiology (PH)
poisoning (PO)
radiation effects (RE)
standards (ST)
supply & distribution (SD)
therapeutic use (TU)
toxicity (TO)
ultrastructure (UL)
urine (UR)
Macromolecular Substances [D05]
Multiprotein Complexes [D05.500]
Polycomb-Group Proteins [D05.500.781]
Polycomb Repressive Complex 1 [D05.500.781.100]
Polycomb Repressive Complex 2 [D05.500.781.750]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Ligases [D08.811.464]
Ubiquitin-Protein Ligase Complexes [D08.811.464.938]
Ubiquitin-Protein Ligases [D08.811.464.938.750]
Anaphase-Promoting Complex-Cyclosome [D08.811.464.938.750.092]
Fanconi Anemia Complementation Group L Protein [D08.811.464.938.750.186]
Inhibitor of Apoptosis Proteins [D08.811.464.938.750.210]
Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein [D08.811.464.938.750.233]
Nedd4 Ubiquitin Protein Ligases [D08.811.464.938.750.257]
Polycomb Repressive Complex 1 [D08.811.464.938.750.280]
Proto-Oncogene Proteins c-cbl [D08.811.464.938.750.374]
Proto-Oncogene Proteins c-mdm2 [D08.811.464.938.750.562]
Receptors, Autocrine Motility Factor [D08.811.464.938.750.656]
Seven in Absentia Proteins [D08.811.464.938.750.703]
SKP Cullin F-Box Protein Ligases [D08.811.464.938.750.750]
Tripartite Motif-Containing Protein 28 [D08.811.464.938.750.782]
Tumor Necrosis Factor alpha-Induced Protein 3 [D08.811.464.938.750.813]
Von Hippel-Lindau Tumor Suppressor Protein [D08.811.464.938.750.875]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Nuclear Proteins [D12.776.660]
Chromosomal Proteins, Non-Histone [D12.776.660.235]
Polycomb-Group Proteins [D12.776.660.235.600]
Polycomb Repressive Complex 1 [D12.776.660.235.600.100]
Polycomb Repressive Complex 2 [D12.776.660.235.600.200]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Nucleoproteins [D12.776.664]
Chromosomal Proteins, Non-Histone [D12.776.664.235]
Polycomb-Group Proteins [D12.776.664.235.800]
Polycomb Repressive Complex 1 [D12.776.664.235.800.100]
Polycomb Repressive Complex 2 [D12.776.664.235.800.200]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Transcription Factors [D12.776.930]
Repressor Proteins [D12.776.930.780]
Polycomb-Group Proteins [D12.776.930.780.890]
Polycomb Repressive Complex 1 [D12.776.930.780.890.100]
Polycomb Repressive Complex 2 [D12.776.930.780.890.200]
Expand All
Collapse All
Polycomb Repressive Complex 1
Preferred
Concept UI
M0499462
Scope Note
A multisubunit polycomb protein complex with affinity for
CHROMATIN
that contains methylated
HISTONE H3
. It contains an E3 ubiquitin ligase activity that is specific for
HISTONE H2A
and works in conjunction with
POLYCOMB REPRESSIVE COMPLEX 2
to effect
EPIGENETIC REPRESSION
.
Terms
Polycomb Repressive Complex 1
Preferred Term
Term UI
T818928
Date
03/05/2012
LexicalTag
NON
ThesaurusID
NLM (2013)
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