- Concept UI
- M000628332
- Registry Numbers
- EC 3.4.22.-
- Scope Note
- A caspase-like cysteine endopeptidase that also exhibits ubiquitin ligase activity. It contains an N-terminal DEATH DOMAIN, two IMMUNOGLOBULIN-LIKE DOMAINS, and localizes to the perinuclear region of MONOCYTES, where it functions in activation of NF-KAPPA B; it also binds to and activates TRAF6. Chromosomal translocations involving the MALT1 and BIRC2 genes are associated with MALT LYMPHOMA, and mutations in the MALT1 gene are associated with Type 12 IMMUNODEFICIENCY SYNDROMES.
- Terms
-
Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
Preferred Term
Term UI
T000919264
Date03/17/2017
LexicalTag
NON
ThesaurusID
NLM (2018)
-
Paracaspase
Term UI
T000919266
Date03/17/2017
LexicalTag
NON
ThesaurusID
NLM (2018)
-
MALT1 Paracaspase
Term UI
T000919267
Date03/17/2017
LexicalTag
ACX
ThesaurusID
NLM (2018)
-
MALT1 Protein
Term UI
T000919269
Date03/17/2017
LexicalTag
ACX
ThesaurusID
NLM (2018)
-
MALT-1 Protein
Term UI
T000919270
Date03/17/2017
LexicalTag
ACX
ThesaurusID
NLM (2018)