MeSH Browser

MeSH Heading: Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
Tree Number(s): D08.811.277.656.262.500.126.775; D08.811.277.656.300.200.126.775; D08.811.464.938.750.233
Unique ID: D000074884
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000074884
Scope Note: A caspase-like cysteine endopeptidase that also exhibits ubiquitin ligase activity. It contains an N-terminal DEATH DOMAIN, two IMMUNOGLOBULIN-LIKE DOMAINS, and localizes to the perinuclear region of MONOCYTES, where it functions in activation of NF-KAPPA B; it also binds to and activates TRAF6. Chromosomal translocations involving the MALT1 and BIRC2 genes are associated with MALT LYMPHOMA, and mutations in the MALT1 gene are associated with Type 12 IMMUNODEFICIENCY SYNDROMES.
Entry Term(s): MALT-1 Protein; MALT1 Paracaspase; MALT1 Protein; Paracaspase
Previous Indexing: Caspases (1999-2017); Neoplasm Proteins (1999-2017)
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/05/22

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000628332
Scope Note: A caspase-like cysteine endopeptidase that also exhibits ubiquitin ligase activity. It contains an N-terminal DEATH DOMAIN, two IMMUNOGLOBULIN-LIKE DOMAINS, and localizes to the perinuclear region of MONOCYTES, where it functions in activation of NF-KAPPA B; it also binds to and activates TRAF6. Chromosomal translocations involving the MALT1 and BIRC2 genes are associated with MALT LYMPHOMA, and mutations in the MALT1 gene are associated with Type 12 IMMUNODEFICIENCY SYNDROMES.
Terms: Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein Preferred Term
Term UI T000919264
Date03/17/2017
LexicalTag NON
ThesaurusID NLM (2018); Paracaspase
Term UI T000919266
Date03/17/2017
LexicalTag NON
ThesaurusID NLM (2018); MALT1 Paracaspase
Term UI T000919267
Date03/17/2017
LexicalTag ACX
ThesaurusID NLM (2018); MALT1 Protein
Term UI T000919269
Date03/17/2017
LexicalTag ACX
ThesaurusID NLM (2018); MALT-1 Protein
Term UI T000919270
Date03/17/2017
LexicalTag ACX
ThesaurusID NLM (2018)

Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein MeSH Descriptor Data 2025