MeSH Browser

MeSH Heading: Inhibitor of Apoptosis Proteins
Tree Number(s): D08.811.464.938.750.210; D12.644.360.075.437; D12.776.476.075.437
Unique ID: D051034
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D051034
Annotation: APOPTOSIS REGULATORY PROTEINS is also available
Scope Note: A conserved class of proteins that control APOPTOSIS in both VERTEBRATES and INVERTEBRATES. IAP proteins interact with and inhibit CASPASES, and they function as ANTI-APOPTOTIC PROTEINS. The protein class is defined by an approximately 80-amino acid motif called the baculoviral inhibitor of apoptosis repeat; some members have ubiquitin-protein ligase activity.
Entry Term(s): BIRC2 Protein; Baculoviral IAP Repeat Containing Protein 2; Baculoviral IAP Repeat-Containing 2 Protein; Baculoviral Inhibitor Of Apoptosis Repeat Proteins; Cellular Inhibitor of Apoptosis 1 Protein; IAP Protein (Apoptosis); IAP Repeat Containing Proteins; IAP2 Protein; Inhibitor of Apoptosis 2 Protein; Inhibitor-Of-Apoptosis Protein; c-IAP1 Protein; cIAP1 Protein
Pharm Action: Caspase Inhibitors
Registry Numbers: 0; EC 2.3.2.27
Related Numbers: EC 2.3.2.27
Public MeSH Note: 2006; INHIBITOR OF APOPTOSIS PROTEINS was indexed under PROTEINS 1997-2005
History Note: 2006(1997)
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2017/06/29

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Ligases [D08.811.464]
    - Ubiquitin-Protein Ligase Complexes [D08.811.464.938]
      - Ubiquitin-Protein Ligases [D08.811.464.938.750]
        
        Anaphase-Promoting Complex-Cyclosome [D08.811.464.938.750.092]
        
        Fanconi Anemia Complementation Group L Protein [D08.811.464.938.750.186]
        
        Inhibitor of Apoptosis Proteins [D08.811.464.938.750.210]
        
        Baculoviral IAP Repeat-Containing 3 Protein [D08.811.464.938.750.210.250]
        
        Neuronal Apoptosis-Inhibitory Protein [D08.811.464.938.750.210.500]
        
        X-Linked Inhibitor of Apoptosis Protein [D08.811.464.938.750.210.750]
        
        Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein [D08.811.464.938.750.233]
        
        Nedd4 Ubiquitin Protein Ligases [D08.811.464.938.750.257]
        
        Polycomb Repressive Complex 1 [D08.811.464.938.750.280]
        
        Proto-Oncogene Proteins c-cbl [D08.811.464.938.750.374]
        
        Proto-Oncogene Proteins c-mdm2 [D08.811.464.938.750.562]
        
        Receptors, Autocrine Motility Factor [D08.811.464.938.750.656]
        
        SKP Cullin F-Box Protein Ligases [D08.811.464.938.750.750]
        
        Tripartite Motif-Containing Protein 28 [D08.811.464.938.750.782]
        
        Tumor Necrosis Factor alpha-Induced Protein 3 [D08.811.464.938.750.813]
        
        Von Hippel-Lindau Tumor Suppressor Protein [D08.811.464.938.750.875]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intracellular Signaling Peptides and Proteins [D12.644.360]
    - Apoptosis Regulatory Proteins [D12.644.360.075]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Apoptosis Regulatory Proteins [D12.776.476.075]

Inhibitor of Apoptosis Proteins Preferred

Concept UI: M0283555
Registry Numbers: 0
Related Numbers: EC 2.3.2.27
Scope Note: A conserved class of proteins that control APOPTOSIS in both VERTEBRATES and INVERTEBRATES. IAP proteins interact with and inhibit CASPASES, and they function as ANTI-APOPTOTIC PROTEINS. The protein class is defined by an approximately 80-amino acid motif called the baculoviral inhibitor of apoptosis repeat; some members have ubiquitin-protein ligase activity.
Terms: Inhibitor of Apoptosis Proteins Preferred Term
Term UI T627089
Date01/07/2005
LexicalTag NON
ThesaurusID NLM (2006); Inhibitor-Of-Apoptosis Protein
Term UI T313560
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2006); IAP Protein (Apoptosis)
Term UI T410003
Date03/21/2000
LexicalTag ABX
ThesaurusID NLM (2006); Baculoviral Inhibitor Of Apoptosis Repeat Proteins
Term UI T631780
Date02/28/2005
LexicalTag NON
ThesaurusID NLM (2006); IAP Repeat Containing Proteins
Term UI T000887861
Date10/13/2015
LexicalTag ABX
ThesaurusID NLM (2017)

Baculoviral IAP Repeat-Containing 2 Protein Narrower

Concept UI: M0479026
Registry Numbers: EC 2.3.2.27
Terms: Baculoviral IAP Repeat-Containing 2 Protein Preferred Term
Term UI T000924047
Date05/11/2017
LexicalTag NON
ThesaurusID NLM (2018); BIRC2 Protein
Term UI T000924048
Date05/11/2017
LexicalTag ABX
ThesaurusID NLM (2018); Cellular Inhibitor of Apoptosis 1 Protein
Term UI T000924049
Date05/11/2017
LexicalTag NON
ThesaurusID NLM (2018); Baculoviral IAP Repeat Containing Protein 2
Term UI T000926384
Date06/07/2017
LexicalTag NON
ThesaurusID NLM (2018); c-IAP1 Protein
Term UI T331369
Date01/01/1955
LexicalTag ABX
ThesaurusID NLM (2006); cIAP1 Protein
Term UI T541118
Date05/17/2003
LexicalTag ABX
ThesaurusID NLM (2006); Inhibitor of Apoptosis 2 Protein
Term UI T627102
Date01/07/2005
LexicalTag NON
ThesaurusID NLM (2006); IAP2 Protein
Term UI T627103
Date01/07/2005
LexicalTag ABX
ThesaurusID NLM (2006)

Inhibitor of Apoptosis Proteins MeSH Descriptor Data 2024