MeSH Browser

MeSH Heading: Baculoviral IAP Repeat-Containing 3 Protein
Tree Number(s): D08.811.464.938.750.210.250; D12.644.360.075.437.250; D12.776.476.075.437.250
Unique ID: D000075747
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000075747
Scope Note: A regulator of APOPTOSIS that functions as an E3 ubiquitin protein ligase. It contains three baculoviral IAP repeats in its N-terminal half, a CARD DOMAIN, and a RING finger domain at its C-terminus. It is highly expressed in fetal lung and kidney, and adult lymphoid tissues such as spleen, thymus, and peripheral blood lymphocytes. It functions in INFLAMMATION signaling, the INNATE IMMUNE RESPONSE, cell growth and proliferation, and metastasis of tumor cells.
Entry Term(s): Apoptosis Inhibitor 2; BIRC3 Protein; Baculoviral IAP Repeat Containing Protein 3; Cellular Inhibitor of Apoptosis-2; Hiap-1 Protein; IAP1 Protein; Inhibitor of Apoptosis 1 Protein; Inhibitor of Apoptosis Protein 1; c-IAP2 Protein; cIAP2 Protein
Pharm Action: Caspase Inhibitors
Registry Numbers: EC 2.3.2.27
Previous Indexing: Inhibitor of Apoptosis Proteins (2006-2017); Ubiquitin-Protein Ligases (2006-2017)
Public MeSH Note: 2018; for INHIBITOR OF APOPTOSIS 1 PROTEIN see INHIBITOR OF OF APOPTOSIS PROTEINS 2006-2017
History Note: 2018; for INHIBITOR OF APOPTOSIS 1 PROTEIN use INHIBITOR OF OF APOPTOSIS PROTEINS 2006-2017
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/29

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
  - Ligases [D08.811.464]
    - Ubiquitin-Protein Ligase Complexes [D08.811.464.938]
      - Ubiquitin-Protein Ligases [D08.811.464.938.750]
        
        Inhibitor of Apoptosis Proteins [D08.811.464.938.750.210]
        
        Baculoviral IAP Repeat-Containing 3 Protein [D08.811.464.938.750.210.250]
        
        Neuronal Apoptosis-Inhibitory Protein [D08.811.464.938.750.210.500]
        
        X-Linked Inhibitor of Apoptosis Protein [D08.811.464.938.750.210.750]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intracellular Signaling Peptides and Proteins [D12.644.360]
    - Apoptosis Regulatory Proteins [D12.644.360.075]
      - Inhibitor of Apoptosis Proteins [D12.644.360.075.437]
        
        Baculoviral IAP Repeat-Containing 3 Protein [D12.644.360.075.437.250]
        
        Neuronal Apoptosis-Inhibitory Protein [D12.644.360.075.437.500]
        
        Survivin [D12.644.360.075.437.625]
        
        X-Linked Inhibitor of Apoptosis Protein [D12.644.360.075.437.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Apoptosis Regulatory Proteins [D12.776.476.075]
      - Inhibitor of Apoptosis Proteins [D12.776.476.075.437]
        
        Baculoviral IAP Repeat-Containing 3 Protein [D12.776.476.075.437.250]
        
        Neuronal Apoptosis-Inhibitory Protein [D12.776.476.075.437.500]
        
        Survivin [D12.776.476.075.437.625]
        
        X-Linked Inhibitor of Apoptosis Protein [D12.776.476.075.437.750]

Baculoviral IAP Repeat-Containing 3 Protein Preferred

Concept UI: M000631361
Registry Numbers: EC 2.3.2.27
Scope Note: A regulator of APOPTOSIS that functions as an E3 ubiquitin protein ligase. It contains three baculoviral IAP repeats in its N-terminal half, a CARD DOMAIN, and a RING finger domain at its C-terminus. It is highly expressed in fetal lung and kidney, and adult lymphoid tissues such as spleen, thymus, and peripheral blood lymphocytes. It functions in INFLAMMATION signaling, the INNATE IMMUNE RESPONSE, cell growth and proliferation, and metastasis of tumor cells.
Terms: Baculoviral IAP Repeat-Containing 3 Protein Preferred Term
Term UI T000923916
Date05/10/2017
LexicalTag ABX
ThesaurusID NLM (2018); BIRC3 Protein
Term UI T000923917
Date05/10/2017
LexicalTag ABX
ThesaurusID NLM (2018); Apoptosis Inhibitor 2
Term UI T000923918
Date05/10/2017
LexicalTag NON
ThesaurusID NLM (2018); Inhibitor of Apoptosis Protein 1
Term UI T000923919
Date05/10/2017
LexicalTag NON
ThesaurusID NLM (2018); cIAP2 Protein
Term UI T000923920
Date05/10/2017
LexicalTag ABX
ThesaurusID NLM (2018); Hiap-1 Protein
Term UI T000923921
Date05/10/2017
LexicalTag ABX
ThesaurusID NLM (2018); Cellular Inhibitor of Apoptosis-2
Term UI T000924051
Date05/11/2017
LexicalTag NON
ThesaurusID NLM (2018); Baculoviral IAP Repeat Containing Protein 3
Term UI T000926383
Date06/07/2017
LexicalTag NON
ThesaurusID NLM (2018); Inhibitor of Apoptosis 1 Protein
Term UI T627095
Date01/07/2005
LexicalTag NON
ThesaurusID NLM (2006); IAP1 Protein
Term UI T627096
Date01/07/2005
LexicalTag ABX
ThesaurusID NLM (2006); c-IAP2 Protein
Term UI T627104
Date01/07/2005
LexicalTag ABX
ThesaurusID NLM (2006)

Baculoviral IAP Repeat-Containing 3 Protein MeSH Descriptor Data 2024