MeSH Browser

MeSH Heading: Beclin-1
Tree Number(s): D12.644.360.075.335; D12.776.094.500; D12.776.476.075.335
Unique ID: D000071186
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071186
Scope Note: An autophagy related protein which functions as a core subunit of PHOSPHATIDYLINOSITOL 3-KINASE MULTIPROTEIN COMPLEXES. It mediates the formation of phosphatidylinositol 3-phosphate and functions in AUTOPHAGY, where it is required for maturation of the AUTOPHAGOSOME. It also functions in ENDOCYTOSIS and CYTOKINESIS as part of a separate complex. Beclin-1 associates with INTRACELLULAR MEMBRANES and interacts with the PROTO-ONCOGENE PROTEINS C-BCL-2 and BCL-X PROTEIN.
Entry Term(s): ATG-6 Protein; ATG6 Protein; Beclin-1 Protein; Beclin1; Coiled-coil Myosin-like Bcl2-interacting Protein; GT197 Protein
Previous Indexing: Apoptosis Regulatory Proteins (2006-2016); Membrane Proteins (2006-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/03/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000613469
Scope Note: An autophagy related protein which functions as a core subunit of PHOSPHATIDYLINOSITOL 3-KINASE MULTIPROTEIN COMPLEXES. It mediates the formation of phosphatidylinositol 3-phosphate and functions in AUTOPHAGY, where it is required for maturation of the AUTOPHAGOSOME. It also functions in ENDOCYTOSIS and CYTOKINESIS as part of a separate complex. Beclin-1 associates with INTRACELLULAR MEMBRANES and interacts with the PROTO-ONCOGENE PROTEINS C-BCL-2 and BCL-X PROTEIN.
Terms: Beclin-1 Preferred Term
Term UI T000893471
Date01/11/2016
LexicalTag NON
ThesaurusID NLM (2017); Beclin-1 Protein
Term UI T000893473
Date01/11/2016
LexicalTag NON
ThesaurusID NLM (2017); ATG6 Protein
Term UI T000893474
Date01/11/2016
LexicalTag ABX
ThesaurusID NLM (2017); ATG-6 Protein
Term UI T000893475
Date01/11/2016
LexicalTag ABX
ThesaurusID NLM (2017); Coiled-coil Myosin-like Bcl2-interacting Protein
Term UI T000893476
Date01/11/2016
LexicalTag NON
ThesaurusID NLM (2017); GT197 Protein
Term UI T000893477
Date01/11/2016
LexicalTag ABX
ThesaurusID NLM (2017); Beclin1
Term UI T000893472
Date01/11/2016
LexicalTag NON
ThesaurusID NLM (2017)

Beclin-1 MeSH Descriptor Data 2025