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Apoptosis Inducing Factor MeSH Descriptor Data 2022


MeSH Heading
Apoptosis Inducing Factor
Tree Number(s)
D08.811.682.608.047
D12.644.360.075.311
D12.776.157.687.063
D12.776.331.161
D12.776.476.075.311
D12.776.660.720.063
Unique ID
D051033
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D051033
Annotation
INHIBITOR OF APOPTOSIS PROTEINS is also available
Scope Note
A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation.
Entry Term(s)
AIF Apoptosis Regulatory Protein
Apoptosis-Inducing Factor
Mitochondrial Apoptosis-Inducing Factor
Registry Number
0
Public MeSH Note
2006; APOPTOSIS INDUCING FACTOR was indexed under FLAVOPROTEINS & MEMBRANE PROTEINS 1999-2005
History Note
2006(1999)
Date Established
2006/01/01
Date of Entry
2005/06/30
Revision Date
2017/05/24
Apoptosis Inducing Factor Preferred
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