MeSH Browser

MeSH Heading: Acetolactate Synthase
Tree Number(s): D08.811.913.200.324; D12.776.331.049
Unique ID: D000095
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000095
Scope Note: A flavoprotein enzyme that catalyzes the formation of acetolactate from 2 moles of PYRUVATE in the biosynthesis of VALINE and the formation of acetohydroxybutyrate from pyruvate and alpha-ketobutyrate in the biosynthesis of ISOLEUCINE. This enzyme was formerly listed as EC 4.1.3.18.
Entry Term(s): Acetohydroxy Acid Synthase; Acetohydroxy Acid Synthetase; Acetohydroxyacid Synthetase I; Acetolactate Synthetase; Acetoxyhydroxyacid Synthase III
Related Numbers: 9027-45-6
CAS Type 1 Name: Acetolactate pyruvate-lyase (carboxylating)
Previous Indexing: Ketoacid-Lyases (1972-1974); Pyruvates (1972-1974)
Public MeSH Note: 91; was see under KETOACID-LYASES 1975-90
History Note: 91(75); was see under KETOACID-LYASES 1975-90
Date Established: 1991/01/01
Date of Entry: 1974/11/11
Revision Date: 2005/06/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0000140
Related Numbers: 9027-45-6
Scope Note: A flavoprotein enzyme that catalyzes the formation of acetolactate from 2 moles of PYRUVATE in the biosynthesis of VALINE and the formation of acetohydroxybutyrate from pyruvate and alpha-ketobutyrate in the biosynthesis of ISOLEUCINE. This enzyme was formerly listed as EC 4.1.3.18.
Terms: Acetolactate Synthase Preferred Term
Term UI T000251
Date01/01/1999
LexicalTag NON
ThesaurusID NLM (1975); Acetohydroxy Acid Synthase
Term UI T000252
Date11/11/1974
LexicalTag NON
ThesaurusID UNK (19XX); Acetohydroxy Acid Synthetase
Term UI T000250
Date11/11/1974
LexicalTag NON
ThesaurusID UNK (19XX); Acetolactate Synthetase
Term UI T000253
Date11/11/1974
LexicalTag NON
ThesaurusID UNK (19XX)

Acetolactate Synthase MeSH Descriptor Data 2025