MeSH Browser

MeSH Heading: NADPH Oxidases
Tree Number(s): D08.811.682.608.575; D12.776.331.894; D12.776.543.653
Unique ID: D019255
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D019255
Scope Note: A family of membrane-associated flavoprotein NADPH-dependent oxidoreductases that catalyze the univalent reduction of OXYGEN to create SUPEROXIDES. Structurally, they are characterized by six N-terminal transmembrane ALPHA-HELICES, a FLAVIN-ADENINE DINUCLEOTIDE (FAD)-binding region, and a C-terminal NADPH-binding region. They are expressed primarily by EPITHELIAL CELLS in gut, kidney, colon, and smooth muscle tissues, as well as GRANULOCYTES and function to transfer electrons across membranes to molecular oxygen. Defects in the production of superoxide ions by some NADPH oxidases result in GRANULOMATOUS DISEASE, CHRONIC.
Entry Term(s): NAD(P)H Oxidases; NAD(P)H oxidase; NADPH Oxidase; Nox Proteins
Previous Indexing: NADH, NADPH Oxidoreductases (1979-1996); NADP (1972-1980); Oxidoreductases (1972-1978)
See Also: Granulomatous Disease, Chronic
Public MeSH Note: 2018; see NADPH OXIDASE 1997-2017; NAD(P)H OXIDASE was indexed under NADH, NADPH OXIDOREDUCTASES 2000-2005; NADPH OXIDASE was indexed under NADH, NADPH OXIDOREDUCTASES 1979-1996, NADP 1972-1980 & OXIDOREDUCTASES 1972-1978
History Note: 2018 (1997)
Date Established: 1997/01/01
Date of Entry: 1996/06/10
Revision Date: 2018/06/12

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0028676
Scope Note: A family of membrane-associated flavoprotein NADPH-dependent oxidoreductases that catalyze the univalent reduction of OXYGEN to create SUPEROXIDES. Structurally, they are characterized by six N-terminal transmembrane ALPHA-HELICES, a FLAVIN-ADENINE DINUCLEOTIDE (FAD)-binding region, and a C-terminal NADPH-binding region. They are expressed primarily by EPITHELIAL CELLS in gut, kidney, colon, and smooth muscle tissues, as well as GRANULOCYTES and function to transfer electrons across membranes to molecular oxygen. Defects in the production of superoxide ions by some NADPH oxidases result in GRANULOMATOUS DISEASE, CHRONIC.
Terms: NADPH Oxidases Preferred Term
Term UI T000916870
Date03/07/2017
LexicalTag ABX
ThesaurusID NLM (2018); Nox Proteins
Term UI T000920963
Date04/05/2017
LexicalTag ABX
ThesaurusID NLM (2018); NAD(P)H Oxidases
Term UI T000916871
Date03/07/2017
LexicalTag ABX
ThesaurusID NLM (2018); NADPH Oxidase
Term UI T057367
Date01/01/1999
LexicalTag ACX
ThesaurusID NLM (1997); NAD(P)H oxidase
Term UI T407268
Date02/16/2000
LexicalTag ACX
ThesaurusID NLM (2006)

NADPH Oxidases MeSH Descriptor Data 2025