MeSH Browser

MeSH Heading: Carbonic Anhydrase IX
Tree Number(s): D08.811.520.241.300.150.450; D12.776.543.178; D23.050.285.196
Unique ID: D000071231
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071231
Scope Note: A carbonic anhydrase and transmembrane protein that consists of an N-terminal PROTEOGLYCAN-like domain, a catalytic region, a single-pass transmembrane domain, and a short intracellular tail. It functions as a dimer and is expressed primarily by cells of the GASTROINTESTINAL TRACT; BILE DUCT EPITHELIUM; and GALL BLADDER. It is expressed at high levels in many solid tumors, especially CLEAR CELL RENAL CARCINOMA, in response to CELL HYPOXIA.
Entry Term(s): CAIX Protein; Carbonic Anhydrase 9
Previous Indexing: Antigens, Neoplasm (1994-2016); Carbonic Anhydrases (1994-2016)
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2016/02/25

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000613753
Scope Note: A carbonic anhydrase and transmembrane protein that consists of an N-terminal PROTEOGLYCAN-like domain, a catalytic region, a single-pass transmembrane domain, and a short intracellular tail. It functions as a dimer and is expressed primarily by cells of the GASTROINTESTINAL TRACT; BILE DUCT EPITHELIUM; and GALL BLADDER. It is expressed at high levels in many solid tumors, especially CLEAR CELL RENAL CARCINOMA, in response to CELL HYPOXIA.
Terms: Carbonic Anhydrase IX Preferred Term
Term UI T000893976
Date01/22/2016
LexicalTag NON
ThesaurusID NLM (2017); Carbonic Anhydrase 9
Term UI T000893977
Date01/22/2016
LexicalTag NON
ThesaurusID NLM (2017); CAIX Protein
Term UI T000893978
Date01/22/2016
LexicalTag NON
ThesaurusID NLM (2017)

Carbonic Anhydrase IX MeSH Descriptor Data 2025