MeSH Browser

MeSH Heading: Fibroblast Activation Protein Alpha
Tree Number(s): D08.811.277.656.300.340; D12.776.543.297
Unique ID: D000099167
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000099167
Scope Note: A large, gelatin-degrading membrane SERINE ENDOPEPTIDASE complex expressed by stromal FIBROBLASTS of epithelial cancers; it is a biomarker for MELANOMA cell invasiveness.
Entry Term(s): FAPalpha; Fibroblast Activation Protein-alpha; Seprase; Surface Expressed Protease
Registry Numbers: EC 3.4.21.-
Public MeSH Note: 2026 (1994); FIBROBLAST ACTIVATION PROTEIN ALPHA was indexed under MEMBRANE PROTEINS and ENDOPEPTIDASES 1994-2025
History Note: 2026 (1994)
Date Introduced: 2026/01/01
Last Updated: 2026/01/01

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000768845
Registry Numbers: EC 3.4.21.-
Scope Note: A large, gelatin-degrading membrane SERINE ENDOPEPTIDASE complex expressed by stromal FIBROBLASTS of epithelial cancers; it is a biomarker for MELANOMA cell invasiveness.
Terms: Fibroblast Activation Protein Alpha Preferred Term
Term UI T001147536
Date03/20/2025
LexicalTag NON
ThesaurusID NLM (2026); FAPalpha
Term UI T261791
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (1994); Fibroblast Activation Protein-alpha
Term UI T001147537
Date03/20/2025
LexicalTag NON
ThesaurusID NLM (2026); Seprase
Term UI T001147538
Date03/20/2025
LexicalTag NON
ThesaurusID NLM (2026); Surface Expressed Protease
Term UI T001147539
Date03/20/2025
LexicalTag NON
ThesaurusID NLM (2026)

Fibroblast Activation Protein Alpha MeSH Descriptor Data 2026