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Dystrophin MeSH Descriptor Data 2023


MeSH Heading
Dystrophin
Tree Number(s)
D12.776.210.500.250
D12.776.220.250
D12.776.543.250
Unique ID
D016189
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D016189
Annotation
a muscle protein: see MeSH definition for relation to musc dystrophy; /‌biosyn /‌drug eff /‌physiol /‌ultrastruct permitted
Scope Note
A muscle protein localized in surface membranes which is the product of the Duchenne/Becker muscular dystrophy gene. Individuals with Duchenne muscular dystrophy usually lack dystrophin completely while those with Becker muscular dystrophy have dystrophin of an altered size. It shares features with other cytoskeletal proteins such as SPECTRIN and alpha-actinin but the precise function of dystrophin is not clear. One possible role might be to preserve the integrity and alignment of the plasma membrane to the myofibrils during muscle contraction and relaxation. MW 400 kDa.
Registry Number
0
Previous Indexing
Muscle Proteins (1988-1990)
See Also
Mice, Inbred mdx
Muscular Dystrophy, Duchenne
Public MeSH Note
91
History Note
91
Date Established
1991/01/01
Date of Entry
1990/06/17
Revision Date
1999/11/03
Dystrophin Preferred
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