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Discs Large Homolog 1 Protein MeSH Descriptor Data 2023


MeSH Heading
Discs Large Homolog 1 Protein
Tree Number(s)
D08.811.913.696.650.450.500
D12.644.360.024.287
D12.776.157.057.023
D12.776.476.024.325
D12.776.543.213
Unique ID
D000074288
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000074288
Scope Note
A signaling adaptor protein that contains three PDZ DOMAINS; an SH3 DOMAIN; and a GUANYLATE KINASE-like C-terminal region. It has an essential role in animal development and recruits ion channels, receptors, and signaling molecules to discrete plasma membrane regions of polarized cells in the HEART ATRIA MYOCARDIUM. It functions in the assembly of ADHERENS JUNCTIONS and regulation of CELL PROLIFERATION; synaptogenesis, LYMPHOCYTE ACTIVATION; and controls expression of KV4 POTASSIUM CHANNELS to regulate excitability of CARDIAC MYOCYTES.
Entry Term(s)
Synapse-Associated Protein 97
Registry Number
0
Previous Indexing
Adaptor Proteins, Signal Transducing (2006-2017)
Membrane Proteins (2006-2017)
Public MeSH Note
2018
History Note
2018
Date Established
2018/01/01
Date of Entry
2017/07/11
Revision Date
2017/02/27
Discs Large Homolog 1 Protein Preferred
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