MeSH Browser

MeSH Heading: 14-3-3 Proteins
Tree Number(s): D12.644.360.024.050; D12.776.157.057.002; D12.776.476.024.050
Unique ID: D048948
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D048948
Scope Note: A large family of signal-transducing adaptor proteins present in wide variety of eukaryotes. They are PHOSPHOSERINE and PHOSPHOTHREONINE binding proteins involved in important cellular processes including SIGNAL TRANSDUCTION; CELL CYCLE control; APOPTOSIS; and cellular stress responses. 14-3-3 proteins function by interacting with other signal-transducing proteins and effecting changes in their enzymatic activity and subcellular localization. The name 14-3-3 derives from numerical designations used in the original fractionation patterns of the proteins.
Entry Term(s): 14-3-3 Protein; 14-3-3 Protein, beta Isoform; 14-3-3 Protein, epsilon Isoform; 14-3-3 Protein, eta Isoform; 14-3-3 Protein, gamma Isoform; 14-3-3 Protein, tau Isoform; 14-3-3 Protein, zeta Isoform; 14-3-3 beta Protein; 14-3-3 epsilon Protein; 14-3-3 eta Protein; 14-3-3 gamma Protein; 14-3-3 tau Protein; 14-3-3 zeta Protein; 14-3-3beta Protein; 14-3-3epsilon Protein; 14-3-3eta Protein; 14-3-3gamma Protein; 14-3-3tau Protein; 14-3-3zeta Protein; Brain 14-3-3 Protein; Protein 14-3-3
Previous Indexing: Nerve Tissue Proteins (1981-1994); Proteins (1995-1999); Tyrosine 3-Monooxygenase (2000-2004)
Public MeSH Note: 2005; 14-3-3 PROTEINS was indexed under TYROSINE 3-MONOOXYGENASE 2000-2004, under PROTEINS 1995-1999, & under NERVE TISSUE PROTEINS 1981-1994
History Note: 2005(1981)
Date Established: 2005/01/01
Date of Entry: 2004/07/07
Revision Date: 2015/11/23

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intracellular Signaling Peptides and Proteins [D12.644.360]
    - Adaptor Proteins, Signal Transducing [D12.644.360.024]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Adaptor Proteins, Signal Transducing [D12.776.157.057]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Adaptor Proteins, Signal Transducing [D12.776.476.024]

14-3-3 Proteins Preferred

Concept UI: M0091246
Scope Note: A large family of signal-transducing adaptor proteins present in wide variety of eukaryotes. They are PHOSPHOSERINE and PHOSPHOTHREONINE binding proteins involved in important cellular processes including SIGNAL TRANSDUCTION; CELL CYCLE control; APOPTOSIS; and cellular stress responses. 14-3-3 proteins function by interacting with other signal-transducing proteins and effecting changes in their enzymatic activity and subcellular localization. The name 14-3-3 derives from numerical designations used in the original fractionation patterns of the proteins.
Terms: 14-3-3 Proteins Preferred Term
Term UI T579074
Date03/25/2004
LexicalTag NON
ThesaurusID NLM (2005); Brain 14-3-3 Protein
Term UI T121246
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2005); Protein 14-3-3
Term UI T121247
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2005); 14-3-3 Protein
Term UI T121249
Date01/01/1955
LexicalTag NON
ThesaurusID NLM (2005)

14-3-3 Protein, tau Isoform Narrower

14-3-3 Protein, zeta Isoform Narrower

14-3-3 Protein, gamma Isoform Narrower

14-3-3 Protein, epsilon Isoform Narrower

14-3-3 Protein, beta Isoform Narrower

14-3-3 Protein, eta Isoform Narrower

14-3-3 Proteins MeSH Descriptor Data 2025