A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share an N-terminal PLECKSTRIN HOMOLOGY DOMAIN, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation, insulin receptor substrate proteins interact with specific SH2 DOMAIN containing proteins that are involved in insulin receptor signaling.
Entry Term(s)
IRS Signaling Adaptor Proteins
Insulin Receptor Substrate-1
Insulin Receptor Substrate-1 Protein
Insulin Receptor Substrate-2
Insulin Receptor Substrate-2 Protein
Insulin Receptor Substrate-3
Insulin Receptor Substrate-3 Protein
Insulin Receptor Substrate-4
Insulin Receptor Substrate-4 Protein
Registry Numbers
0
Previous Indexing
Adaptor Proteins, Signal Transducing (2008)
Phosphoproteins (1992-2008)
Public MeSH Note
2009; INSULIN RECEPTOR SUBSTRATE-1 PROTEIN was indexed under PHOSPHOPROTEINS 1992-2008, & under ADAPTOR PROTEINS, SIGNAL TRANSDUCING 2008; INSULIN RECEPTOR SUBSTRATE-2 PROTEIN was indexed under PHOSPHOPROTEINS 1995-2008, & under ADAPTOR PROTEINS, SIGNAL TRANSDUCING 2008
A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share an N-terminal PLECKSTRIN HOMOLOGY DOMAIN, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation, insulin receptor substrate proteins interact with specific SH2 DOMAIN containing proteins that are involved in insulin receptor signaling.
