MeSH Browser

MeSH Heading: mTOR Associated Protein, LST8 Homolog
Tree Number(s): D05.500.337.250; D08.811.913.696.620.682.700.931.500.250; D12.644.360.024.310; D12.776.157.057.073; D12.776.476.024.389; D12.776.476.563.931.500.250
Unique ID: D000076242
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000076242
Scope Note: An adaptor protein, consisting of seven WD REPEATS along its length, that functions as a component of the MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1 and mTORC2 COMPLEX. It interacts directly with mTOR to enhance its kinase activity and stabilizes the mTOR-RPTOR PROTEIN interaction in nutrient-poor conditions, favoring RPTOR inhibition of mTOR activity.
Entry Term(s): G protein beta Subunit-like Polypeptide; GBetaL Protein; mLST8 Protein
Registry Number: 0
Previous Indexing: Adaptor Proteins, Signal Transducing (2013-2017); Proteins (2011-2017)
Public MeSH Note: 2018
History Note: 2018
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2021/05/21

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000632423
Registry Number: 0
Scope Note: An adaptor protein, consisting of seven WD REPEATS along its length, that functions as a component of the MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1 and mTORC2 COMPLEX. It interacts directly with mTOR to enhance its kinase activity and stabilizes the mTOR-RPTOR PROTEIN interaction in nutrient-poor conditions, favoring RPTOR inhibition of mTOR activity.
Terms: mTOR Associated Protein, LST8 Homolog Preferred Term
Term UI T000946337
Date09/02/2018
LexicalTag NON
ThesaurusID NLM (2020); G protein beta Subunit-like Polypeptide
Term UI T000925753
Date05/31/2017
LexicalTag NON
ThesaurusID NLM (2018); GBetaL Protein
Term UI T000925752
Date05/31/2017
LexicalTag ABX
ThesaurusID NLM (2018); mLST8 Protein
Term UI T000925751
Date05/31/2017
LexicalTag ABX
ThesaurusID NLM (2018)

mTOR Associated Protein, LST8 Homolog MeSH Descriptor Data 2023