- Concept UI
- M0204531
- Scope Note
- A signal transducing adaptor protein that links extracellular signals to the MAP KINASE SIGNALING SYSTEM. Grb2 associates with activated EPIDERMAL GROWTH FACTOR RECEPTOR and PLATELET-DERIVED GROWTH FACTOR RECEPTORS via its SH2 DOMAIN. It also binds to and translocates the SON OF SEVENLESS PROTEINS through its SH3 DOMAINS to activate PROTO-ONCOGENE PROTEIN P21(RAS).
- Terms
-
GRB2 Adaptor Protein
Preferred Term
Term UI
T578937
Date03/24/2004
LexicalTag
ABX
ThesaurusID
NLM (2006)
-
Abundant Src Homology Protein
Term UI
T234535
Date01/01/1955
LexicalTag
NON
ThesaurusID
NLM (2006)
-
Growth Factor Receptor-Bound Protein-2
Term UI
T234536
Date01/01/1955
LexicalTag
NON
ThesaurusID
NLM (2006)