MeSH Browser

MeSH Heading: Nod Signaling Adaptor Proteins
Tree Number(s): D12.644.360.024.313; D12.644.360.539.500; D12.776.157.057.078; D12.776.476.024.391
Unique ID: D053472
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D053472
Scope Note: Cytosolic signaling adaptor proteins that were initially discovered by their role in the innate immunity (IMMUNITY, INNATE) response of organisms that lack an adaptive immune system. This class of proteins contains three domains, a C-terminal ligand recognition domain, an N-terminal effector-binding domain, and a centrally located nuclear-binding oligomerization domain. Many members of this class contain a C-terminal leucine rich domain which binds to PEPTIDOGLYCAN on the surface of BACTERIA and plays a role in pathogen resistance.
Entry Term(s): NOD Leucine-Rich Repeat Proteins; NOD-LRR Signaling Adaptor Proteins; Nuclear-Binding Oligomerization Domain Proteins; Nucleotide Oligomerization Domain Proteins
Public MeSH Note: 2007
History Note: 2007
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2016/03/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M0493381
Scope Note: Cytosolic signaling adaptor proteins that were initially discovered by their role in the innate immunity (IMMUNITY, INNATE) response of organisms that lack an adaptive immune system. This class of proteins contains three domains, a C-terminal ligand recognition domain, an N-terminal effector-binding domain, and a centrally located nuclear-binding oligomerization domain. Many members of this class contain a C-terminal leucine rich domain which binds to PEPTIDOGLYCAN on the surface of BACTERIA and plays a role in pathogen resistance.
Terms: Nod Signaling Adaptor Proteins Preferred Term
Term UI T663300
Date12/28/2005
LexicalTag ACX
ThesaurusID NLM (2007); Nuclear-Binding Oligomerization Domain Proteins
Term UI T663305
Date12/28/2005
LexicalTag NON
ThesaurusID NLM (2007); Nucleotide Oligomerization Domain Proteins
Term UI T666902
Date02/23/2006
LexicalTag NON
ThesaurusID NLM (2007)

Nod Signaling Adaptor Proteins MeSH Descriptor Data 2025