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NLR Family, Pyrin Domain-Containing 3 Protein MeSH Descriptor Data 2023


MeSH Heading
NLR Family, Pyrin Domain-Containing 3 Protein
Tree Number(s)
D12.644.360.539.250
Unique ID
D000071199
RDF Unique Identifier
http://id.nlm.nih.gov/mesh/D000071199
Scope Note
An NLR protein that contains an N-terminal PYRIN DOMAIN and ATP-binding site and 9 C-terminal LEUCINE-rich repeats; it is expressed primarily by MACROPHAGES. It is a core component of the INFLAMMASOME and directs its assembly in response to pathogen infection and damage-associated stimuli. Mutations in the NLRP3 gene are associated with FAMILIAL COLD AUTOINFLAMMATORY SYNDROME.
Entry Term(s)
Cold Autoinflammatory Syndrome 1 Protein
NACHT, LRR and PYD Domains-Containing Protein 3
NLRP3 Protein
Registry Number
0
Previous Indexing
Carrier Proteins (2002-2016)
See Also
Cryopyrin-Associated Periodic Syndromes
Inflammasomes
Public MeSH Note
2017
History Note
2017
Date Established
2017/01/01
Date of Entry
2016/07/08
Revision Date
2017/02/24
NLR Family, Pyrin Domain-Containing 3 Protein Preferred
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