MeSH Browser

MeSH Heading: NLR Family, Pyrin Domain-Containing 3 Protein
Tree Number(s): D12.644.360.539.250
Unique ID: D000071199
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D000071199
Scope Note: An NLR protein that contains an N-terminal PYRIN DOMAIN and ATP-binding site and 9 C-terminal LEUCINE-rich repeats; it is expressed primarily by MACROPHAGES. It is a core component of the INFLAMMASOME and directs its assembly in response to pathogen infection and damage-associated stimuli. Mutations in the NLRP3 gene are associated with FAMILIAL COLD AUTOINFLAMMATORY SYNDROME.
Entry Term(s): Cold Autoinflammatory Syndrome 1 Protein; NACHT, LRR and PYD Domains-Containing Protein 3; NLRP3 Protein
Previous Indexing: Carrier Proteins (2002-2016)
See Also: Cryopyrin-Associated Periodic Syndromes; Inflammasomes
Public MeSH Note: 2017
History Note: 2017
Date Established: 2017/01/01
Date of Entry: 2016/07/08
Revision Date: 2017/02/24

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Concept UI: M000613582
Scope Note: An NLR protein that contains an N-terminal PYRIN DOMAIN and ATP-binding site and 9 C-terminal LEUCINE-rich repeats; it is expressed primarily by MACROPHAGES. It is a core component of the INFLAMMASOME and directs its assembly in response to pathogen infection and damage-associated stimuli. Mutations in the NLRP3 gene are associated with FAMILIAL COLD AUTOINFLAMMATORY SYNDROME.
Terms: NLR Family, Pyrin Domain-Containing 3 Protein Preferred Term
Term UI T000893693
Date01/15/2016
LexicalTag NON
ThesaurusID NLM (2017); NLRP3 Protein
Term UI T000893694
Date01/15/2016
LexicalTag ABX
ThesaurusID NLM (2017); Cold Autoinflammatory Syndrome 1 Protein
Term UI T000893695
Date01/15/2016
LexicalTag NON
ThesaurusID NLM (2017); NACHT, LRR and PYD Domains-Containing Protein 3
Term UI T000893696
Date01/15/2016
LexicalTag NON
ThesaurusID NLM (2017)

NLR Family, Pyrin Domain-Containing 3 Protein MeSH Descriptor Data 2025