- Concept UI
- M000613582
- Registry Numbers
- 0
- Scope Note
- An NLR protein that contains an N-terminal PYRIN DOMAIN and ATP-binding site and 9 C-terminal LEUCINE-rich repeats; it is expressed primarily by MACROPHAGES. It is a core component of the INFLAMMASOME and directs its assembly in response to pathogen infection and damage-associated stimuli. Mutations in the NLRP3 gene are associated with FAMILIAL COLD AUTOINFLAMMATORY SYNDROME.
- Terms
-
NLR Family, Pyrin Domain-Containing 3 Protein
Preferred Term
Term UI
T000893693
Date01/15/2016
LexicalTag
NON
ThesaurusID
NLM (2017)
-
NLRP3 Protein
Term UI
T000893694
Date01/15/2016
LexicalTag
ABX
ThesaurusID
NLM (2017)
-
Cold Autoinflammatory Syndrome 1 Protein
Term UI
T000893695
Date01/15/2016
LexicalTag
NON
ThesaurusID
NLM (2017)
-
NACHT, LRR and PYD Domains-Containing Protein 3
Term UI
T000893696
Date01/15/2016
LexicalTag
NON
ThesaurusID
NLM (2017)