MeSH Browser

MeSH Heading: Nod2 Signaling Adaptor Protein
Tree Number(s): D12.644.360.024.131.500; D12.644.360.024.313.500; D12.644.360.075.358.500; D12.644.360.539.500.500; D12.776.157.057.006.500; D12.776.157.057.078.500; D12.776.476.024.139.500; D12.776.476.024.391.500; D12.776.476.075.358.500
Unique ID: D053473
RDF Unique Identifier: http://id.nlm.nih.gov/mesh/D053473
Scope Note: A NOD signaling adaptor protein that contains two C-terminal leucine-rich domains which recognize bacterial PEPTIDOGLYCAN. It signals via an N-terminal capase recruitment domain that interacts with other CARD SIGNALING ADAPTOR PROTEINS such as RIP SERINE-THEONINE KINASES. The protein plays a role in the host defense response by signaling the activation of CASPASES and the MAP KINASE SIGNALING SYSTEM. Mutations of the gene encoding the nucleotide oligomerization domain 2 protein have been associated with increased susceptibility to CROHN DISEASE.
Entry Term(s): CARD15 Protein; Caspase Recruitment Domain Protein 15; Nucleotide Oligomerization Domain 2 Protein
Previous Indexing: Carrier Proteins (2001-2004); Intracellular Signaling Peptides and Proteins (2005-2006)
Public MeSH Note: 2007
History Note: 2007
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2016/03/30

Allowable Qualifiers: administration & dosage (AD)

adverse effects (AE)

agonists (AG)

analysis (AN)

antagonists & inhibitors (AI)

biosynthesis (BI)

blood (BL)

cerebrospinal fluid (CF)

chemical synthesis (CS)

chemistry (CH)

classification (CL)

deficiency (DF)

drug effects (DE)

economics (EC)

genetics (GE)

history (HI)

immunology (IM)

isolation & purification (IP)

metabolism (ME)

pharmacokinetics (PK)

pharmacology (PD)

physiology (PH)

poisoning (PO)

radiation effects (RE)

standards (ST)

supply & distribution (SD)

therapeutic use (TU)

toxicity (TO)

ultrastructure (UL)

urine (UR)

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intracellular Signaling Peptides and Proteins [D12.644.360]
    - Adaptor Proteins, Signal Transducing [D12.644.360.024]
      - CARD Signaling Adaptor Proteins [D12.644.360.024.131]
        
        Apoptotic Protease-Activating Factor 1 [D12.644.360.024.131.124]
        
        B-Cell CLL-Lymphoma 10 Protein [D12.644.360.024.131.140]
        
        CRADD Signaling Adaptor Protein [D12.644.360.024.131.186]
        
        Nod1 Signaling Adaptor Protein [D12.644.360.024.131.249]
        
        Nod2 Signaling Adaptor Protein [D12.644.360.024.131.500]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intracellular Signaling Peptides and Proteins [D12.644.360]
    - Adaptor Proteins, Signal Transducing [D12.644.360.024]
      - Nod Signaling Adaptor Proteins [D12.644.360.024.313]
        
        Nod1 Signaling Adaptor Protein [D12.644.360.024.313.249]
        
        Nod2 Signaling Adaptor Protein [D12.644.360.024.313.500]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intracellular Signaling Peptides and Proteins [D12.644.360]
    - Apoptosis Regulatory Proteins [D12.644.360.075]
      - CARD Signaling Adaptor Proteins [D12.644.360.075.358]
        
        Apoptotic Protease-Activating Factor 1 [D12.644.360.075.358.124]
        
        B-Cell CLL-Lymphoma 10 Protein [D12.644.360.075.358.140]
        
        CRADD Signaling Adaptor Protein [D12.644.360.075.358.186]
        
        Nod1 Signaling Adaptor Protein [D12.644.360.075.358.249]
        
        Nod2 Signaling Adaptor Protein [D12.644.360.075.358.500]

Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
  - Intracellular Signaling Peptides and Proteins [D12.644.360]
    - NLR Proteins [D12.644.360.539]
      - Nod Signaling Adaptor Proteins [D12.644.360.539.500]
        
        Nod1 Signaling Adaptor Protein [D12.644.360.539.500.249]
        
        Nod2 Signaling Adaptor Protein [D12.644.360.539.500.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Adaptor Proteins, Signal Transducing [D12.776.157.057]
      - CARD Signaling Adaptor Proteins [D12.776.157.057.006]
        
        Apoptotic Protease-Activating Factor 1 [D12.776.157.057.006.124]
        
        B-Cell CLL-Lymphoma 10 Protein [D12.776.157.057.006.140]
        
        Caspase 9 [D12.776.157.057.006.155]
        
        CRADD Signaling Adaptor Protein [D12.776.157.057.006.186]
        
        Nod1 Signaling Adaptor Protein [D12.776.157.057.006.249]
        
        Nod2 Signaling Adaptor Protein [D12.776.157.057.006.500]
        
        Receptor-Interacting Protein Serine-Threonine Kinase 2 [D12.776.157.057.006.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Carrier Proteins [D12.776.157]
    - Adaptor Proteins, Signal Transducing [D12.776.157.057]
      - Nod Signaling Adaptor Proteins [D12.776.157.057.078]
        
        Nod1 Signaling Adaptor Protein [D12.776.157.057.078.249]
        
        Nod2 Signaling Adaptor Protein [D12.776.157.057.078.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Adaptor Proteins, Signal Transducing [D12.776.476.024]
      - CARD Signaling Adaptor Proteins [D12.776.476.024.139]
        
        Apoptotic Protease-Activating Factor 1 [D12.776.476.024.139.124]
        
        B-Cell CLL-Lymphoma 10 Protein [D12.776.476.024.139.140]
        
        Caspase 9 [D12.776.476.024.139.155]
        
        CRADD Signaling Adaptor Protein [D12.776.476.024.139.186]
        
        Nod1 Signaling Adaptor Protein [D12.776.476.024.139.249]
        
        Nod2 Signaling Adaptor Protein [D12.776.476.024.139.500]
        
        Receptor-Interacting Protein Serine-Threonine Kinase 2 [D12.776.476.024.139.750]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Adaptor Proteins, Signal Transducing [D12.776.476.024]
      - Nod Signaling Adaptor Proteins [D12.776.476.024.391]
        
        Nod1 Signaling Adaptor Protein [D12.776.476.024.391.249]
        
        Nod2 Signaling Adaptor Protein [D12.776.476.024.391.500]

Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
  - Intracellular Signaling Peptides and Proteins [D12.776.476]
    - Apoptosis Regulatory Proteins [D12.776.476.075]
      - CARD Signaling Adaptor Proteins [D12.776.476.075.358]
        
        Apoptotic Protease-Activating Factor 1 [D12.776.476.075.358.124]
        
        B-Cell CLL-Lymphoma 10 Protein [D12.776.476.075.358.140]
        
        Caspase 9 [D12.776.476.075.358.155]
        
        CRADD Signaling Adaptor Protein [D12.776.476.075.358.186]
        
        Nod1 Signaling Adaptor Protein [D12.776.476.075.358.249]
        
        Nod2 Signaling Adaptor Protein [D12.776.476.075.358.500]
        
        Receptor-Interacting Protein Serine-Threonine Kinase 2 [D12.776.476.075.358.750]

Nod2 Signaling Adaptor Protein Preferred

Concept UI: M0493385
Scope Note: A NOD signaling adaptor protein that contains two C-terminal leucine-rich domains which recognize bacterial PEPTIDOGLYCAN. It signals via an N-terminal capase recruitment domain that interacts with other CARD SIGNALING ADAPTOR PROTEINS such as RIP SERINE-THEONINE KINASES. The protein plays a role in the host defense response by signaling the activation of CASPASES and the MAP KINASE SIGNALING SYSTEM. Mutations of the gene encoding the nucleotide oligomerization domain 2 protein have been associated with increased susceptibility to CROHN DISEASE.
Terms: Nod2 Signaling Adaptor Protein Preferred Term
Term UI T663323
Date12/28/2005
LexicalTag ABX
ThesaurusID NLM (2007); Nucleotide Oligomerization Domain 2 Protein
Term UI T663308
Date12/28/2005
LexicalTag NON
ThesaurusID NLM (2007); Caspase Recruitment Domain Protein 15
Term UI T663309
Date12/28/2005
LexicalTag NON
ThesaurusID NLM (2007); CARD15 Protein
Term UI T663310
Date12/28/2005
LexicalTag ABX
ThesaurusID NLM (2007)

Nod2 Signaling Adaptor Protein MeSH Descriptor Data 2025